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Updated: Jul 5, 2026

Interactions with and Membrane Permeabilization of Brain Mitochondria by Amyloid Fibrils
Published on: September 28, 2019
A connection between the mitochondrial permeability transition pore, autophagy, and cerebral amyloidogenesis
Vukić Soskić1, Martina Klemm, Tassula Proikas-Cezanne
1ProteoSys AG, Carl Zeiss Strasse 51, D-55129 Mainz, Germany.
Abstract:
In a drug reprofiling attempt, we explored novel neuroprotective properties of 4-azasteroids by synthesizing chemical affinity tags capturing adenine nucleotide translocator-1, as a potential target. Dutasteride inhibits the mitochondrial transition pore and induces an increase of autophagosomal structures in human cell lines. In vivo, a surprising reduction of the beta-amyloid plaque load in a model for cerebral amyloidosis appears to connect release of neurotoxic peptides, mitochondrial apoptosis and autophagy.
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