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Related Concept Videos

Cardiomyopathy II: Dilated Cardiomyopathy01:30

Cardiomyopathy II: Dilated Cardiomyopathy

Dilated cardiomyopathy, or DCM, is a progressive myocardial disorder characterized by ventricular chamber dilation and contractile dysfunction.EtiologyVarious factors can cause DCM, including hypertension and heavy alcohol intake, which contribute to the weakening and enlargement of the heart muscle. Viral infections, such as Coxsackievirus B, adenoviruses, and influenza, can lead to DCM by causing inflammation and damage to heart tissue. Certain chemotherapeutic agents, including daunorubicin,...
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Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
Cardiomyopathy IV: Restrictive Cardiomyopathy01:29

Cardiomyopathy IV: Restrictive Cardiomyopathy

Restrictive cardiomyopathy (RCM) is a rare heart muscle disease characterized by impaired ventricular filling due to stiffened ventricular walls, leading to significant diastolic dysfunction.EtiologyRestrictive cardiomyopathy can arise from both inherited and acquired diseases, many of which are systemic. It is categorized into four main types: infiltrative, storage, non-infiltrative, and endomyocardial diseases.Infiltrative diseases, such as amyloidosis, lead to RCM by depositing amyloid...
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Cardiomyopathy, or CMP, is a group of diseases affecting the myocardial structure, impairing its ability to pump blood effectively. This condition can lead to arrhythmias, heart failure, or sudden cardiac death.Cardiomyopathies are classified into primary and secondary categories:Primary Cardiomyopathy refers to conditions involving only the heart muscle that are often idiopathic (of unknown cause) or genetic. They primarily affect the myocardium without the involvement of other systemic...

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Updated: Jul 5, 2026

Identification of Neutrophil Extracellular Traps in Paraffin-Embedded Feline Arterial Thrombi using Immunofluorescence Microscopy
08:48

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Published on: March 29, 2020

Hypercoagulability in cats with cardiomyopathy.

T Stokol1, M Brooks, J E Rush

  • 1Department of Population Medicine and Diagnostic Sciences, Cornell University, Ithaca, NY 14853, USA. ts23@cornell.edu

Journal of Veterinary Internal Medicine
|May 10, 2008
PubMed
Summary
This summary is machine-generated.

Systemic hypercoagulability is a risk factor for arterial thromboembolism (ATE) in cats with cardiomyopathy. This hypercoagulability, indicated by coagulation abnormalities, occurs even without congestive heart failure or overt ATE.

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Published on: March 12, 2018

Area of Science:

  • Veterinary Cardiology
  • Feline Medicine
  • Thrombosis Research

Background:

  • Arterial thromboembolism (ATE) is a frequent complication of feline cardiomyopathy, but its underlying causes remain unclear.
  • Understanding the pathogenesis of ATE is crucial for managing affected cats.

Purpose of the Study:

  • To investigate the role of systemic hypercoagulability and endothelial injury in the development of ATE in cardiomyopathic cats.
  • To identify laboratory markers associated with ATE in this population.

Main Methods:

  • Compared healthy cats (n=30) with three groups of cardiomyopathic cats: left atrial enlargement (LAE), LAE with spontaneous echocardiographic contrast/thrombi (SEC-T), and acute ATE with LAE.
  • Assessed hypercoagulability via fibrinogen, Factor VIII, antithrombin, thrombin-antithrombin complex (TAT), and d-dimer levels.
  • Measured von Willebrand factor antigen (vWF:Ag) as a marker of endothelial injury.

Main Results:

  • Cats with cardiac disease showed higher fibrinogen levels than healthy controls.
  • Hypercoagulability was present in 50% of SEC-T cats and 56% of ATE cats.
  • ATE cats exhibited significantly higher vWF:Ag concentrations, suggesting endothelial injury.

Conclusions:

  • Systemic hypercoagulability is common in cardiomyopathic cats, potentially preceding overt ATE or congestive heart failure (CHF).
  • Hypercoagulability is identified as a significant risk factor for ATE in cats.
  • Elevated vWF:Ag in ATE cats is likely due to endothelial damage caused by the thrombus.