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[Immune-mediated inflammatory diseases and psoriasis].
1Université de Lille II et Clinique de Dermatologie, Hôpital Claude-Huriez, CHRU, Rue Michel Polonovski, 59037 Lille cedex. edelaporte@chru-lille.fr
Annales De Dermatologie Et De Venereologie
|May 24, 2008
Summary
Psoriasis often co-occurs with immune-mediated inflammatory diseases like Crohn's disease and spondyloarthropathies. Shared genetic, immunologic, and potential bacterial triggers link these conditions, guiding biologic therapies.
Area of Science:
- Immunology
- Genetics
- Dermatology
Context:
- Immune-mediated inflammatory diseases (IMIDs) can co-occur in a single patient.
- Psoriasis association with other IMIDs is challenging to study prospectively.
- Strongest links exist between psoriasis, Crohn's disease, and spondyloarthropathies.
Purpose:
- To explore the shared underlying mechanisms and associations between psoriasis and other immune-mediated inflammatory diseases.
- To consolidate evidence from genetic, immunologic, and environmental factors linking these conditions.
Summary:
- Genetic studies reveal shared loci and genes in innate immunity across psoriasis, Crohn's disease, and spondyloarthropathies.
- Immunologic data highlight shared effector cells like Th17 lymphocytes and inflammatory mediators (e.g., TNF-alpha, IL-1, IL-17, IL-23).
- Bacterial infections are hypothesized as environmental triggers contributing to the pathogenesis of these interconnected diseases.
Impact:
- Understanding these links supports the efficacy of current biologic therapies targeting shared inflammatory pathways (e.g., anti-TNF-alpha, anti-IL-12/23).
- Identifies potential targets for novel therapeutic strategies.
- Provides a framework for future prospective studies on co-occurring IMIDs.
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