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Incomplete Dominance01:43

Incomplete Dominance

Gregor Mendel's work (1822 - 1884) was primarily focused on pea plants. Through his initial experiments, he determined that every gene in a diploid cell has two variants called alleles inherited from each parent. He suggested that amongst these two alleles, one allele is dominant in character and the other recessive. The combination of alleles determines the phenotype of a gene in an organism.
Animal Mitochondrial Genetics02:59

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Among all the organelles in an animal cell, only mitochondria have their own independent genomes. Animal mitochondrial DNA is a double-stranded, closed-circular molecule with around 20,000 base pairs. Mitochondrial DNA is unique in that one of its two strands, the heavy, or H, -strand is guanine rich, whereas the complementary strand is cytosine rich and called the light, or L, -strand. Compared to nuclear DNA, mitochondrial DNA has a very low percentage of non-coding regions and is marked by...
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The human X chromosome contains over ten times the number of genes as in the Y chromosome. Since males have only one X chromosome, and females have two, one might expect females to produce twice as many of the proteins, with undesirable results.
Genomics02:02

Genomics

Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...
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Chromatin Immunoprecipitation of Murine Brown Adipose Tissue
07:50

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Published on: November 21, 2018

State of cat genomics.

Stephen J O'Brien1, Warren Johnson, Carlos Driscoll

  • 1Laboratory of Genomic Diversity, National Cancer Institute, Frederick, MD 21702, USA. obrien@ncifcrf.gov

Trends in Genetics : TIG
|May 13, 2008
PubMed
Summary

A new cat genome sequence aids in understanding Felidae biology, domestication, and conservation. This genomics resource offers insights into cat evolution and disease gene discovery.

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Area of Science:

  • Genomics
  • Comparative Genomics
  • Evolutionary Biology

Background:

  • The completion of a draft whole genome sequence for the Abyssinian cat has significantly advanced the study of cat family (Felidae) biology.
  • Genomic information is crucial for understanding domestication, genetic diversity, and conservation efforts within the Felidae family.

Purpose of the Study:

  • To review recent advances in cat genomics and its applications.
  • To highlight the utility of the cat genome in disease gene discovery, comparative genomics, and species conservation.

Main Methods:

  • Whole genome sequencing of an Abyssinian cat.
  • Analysis of genomic organization patterns in domestic cat breeds and Felidae species.
  • Comparative genomic analyses.

Main Results:

  • The cat genome has facilitated disease gene discovery and comparative genomics studies.
  • Genomic patterns reveal insights into cat domestication, breed formation, and chromosomal evolution.
  • Evidence suggests ancestral continental migration events shaping modern Felidae species.

Conclusions:

  • The developing cat genome resources are valuable tools for genetics and biology research.
  • The cat genome is poised to make significant contributions to various scientific fields.
  • Genomic insights are essential for the conservation of the 37 modern species of Felidae.