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Related Experiment Video

Updated: Jul 5, 2026

Assay Development for High-Throughput Drug Screening Against Mycobacteria

Assay Development for High-Throughput Drug Screening Against Mycobacteria

Published on: October 25, 2024

Epothilones: clinical update and future directions.

Diana Donovan¹, Linda T Vahdat

¹Weill Cornell Breast Center, Cornell University/ New York-Presbyterian Hospital, New York, NY 10021, USA. donovdi@med.cornell.edu

Oncology (Williston Park, N.Y.)

|May 14, 2008

Summary

Epothilones are promising cancer drugs that work differently than taxanes, offering hope for patients with resistant tumors. Clinical trials are exploring their use, with ixabepilone already approved for breast cancer.

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Last Updated: Jul 5, 2026

Assay Development for High-Throughput Drug Screening Against Mycobacteria

Assay Development for High-Throughput Drug Screening Against Mycobacteria

Published on: October 25, 2024

Area of Science:

Oncology
Pharmacology
Molecular Biology

Background:

Epothilones are cytotoxic compounds similar to paclitaxel.
They induce microtubule bundling and apoptotic cell death.
Their distinct mechanism offers potential against taxane-resistant cancers.

Purpose of the Study:

Review recent clinical findings on epothilones.
Discuss future directions for epothilone cancer therapy.
Focus on ixabepilone and patupilone.

Main Methods:

Review of clinical trial data.
Analysis of epothilone mechanisms of action.
Focus on ixabepilone and patupilone.

Main Results:

Several epothilones tested in solid tumors.
Ixabepilone approved for metastatic/locally advanced breast cancer.
Ixabepilone effective in monotherapy and combination treatments.

Conclusions:

Epothilones represent a valuable drug class for cancer treatment.
Their unique mechanism is crucial for overcoming taxane resistance.
Further research into ixabepilone and patupilone is warranted.