Related Experiment Video
Updated: Jul 5, 2026

06:27
A Retrograde Implantation Approach for Peritoneal Dialysis Catheter Placement in Mice
Published on: July 20, 2022
[Should dialysis be for all? Yes indeed!]
G Panzetta1, M Grignetti, G Toigo
1S.C. di Nefrologia e Dialisi, Azienda Ospedaliero-Universitaria Ospedali Riuniti di Trieste, Trieste, Italy.
Summary
Dialysis for patients over 75 is ethically complex, not clinically limited. Despite challenges, survival and rehabilitation for the very elderly are comparable to younger groups, emphasizing quality of life over technical constraints.
Area of Science:
- Nephrology
- Geriatrics
- Bioethics
Context:
- Chronic dialysis patients, especially the very elderly (over 75), present unique challenges.
- This demographic constitutes a significant and growing proportion of dialysis patients in Europe.
- Their complex medical, social, and functional needs strain healthcare resources.
Purpose:
- To examine the indications and limitations of chronic dialysis in very elderly patients.
- To compare the survival and rehabilitation outcomes of the very elderly with younger dialysis cohorts.
- To explore the ethical considerations surrounding dialysis in advanced age.
Summary:
- Patients over 75 undergoing dialysis exhibit survival and rehabilitation rates comparable to those aged 65-75, excluding the oldest (over 85).
- Many age-related impairments are due to aging itself, not uremia or dialysis.
- Healthcare systems face significant resource strain due to the complex needs of these patients.
Impact:
- The decision to initiate dialysis in the very elderly should prioritize quality of life and avoid futility.
- Ethical considerations, rather than clinical or economic factors, should guide dialysis decisions for critically ill patients.
- Nephrologists must balance patient suffering alleviation with societal support capacity.
Related Concept Videos
Dialysis
Renal failure occurs when the kidneys lose their ability to filter waste products from the blood effectively. It can be classified into two types: acute renal failure (ARF) and chronic renal failure (CRF).
Acute kidney injury develops suddenly and can be caused by pre-renal causes (e.g., hypovolemia, shock), intrinsic renal causes (e.g., acute tubular necrosis), or post-renal causes (e.g., urinary obstruction). In contrast, chronic renal failure progresses gradually over time and is often...
Acute kidney injury develops suddenly and can be caused by pre-renal causes (e.g., hypovolemia, shock), intrinsic renal causes (e.g., acute tubular necrosis), or post-renal causes (e.g., urinary obstruction). In contrast, chronic renal failure progresses gradually over time and is often...
Dialysis
Dialysis is a diffusion-based purification process that separates analyte molecules from a complex matrix. This is accomplished by allowing molecules in the solution to pass through a semipermeable membrane into a liquid on the other side. The membrane is usually made of cellulose acetate or cellulose nitrate, and the second liquid must be miscible with the solution. Ions (e.g., chloride or sodium) or organic molecules (e.g., glucose) can pass through the membrane pores, which generally have...
Hemodialysis I: Introduction
Hemodialysis (HD) is a medical treatment that artificially removes waste products, excess fluids, and toxins from the blood when the kidneys are no longer able to perform these functions effectively. In this process, blood is filtered through a semipermeable membrane, allowing for the selective removal of waste while preserving necessary components like blood cells and proteins. Hemodialysis is typically performed in patients with end-stage renal disease (ESRD) or severe kidney...
Hemodialysis II: Procedure and Complications
DialyzersA hemodialysis (HD) dialyzer is a plastic cartridge containing thousands of parallel hollow fibers, which serve as semipermeable membranes. These fibers are typically made from cellulose-based or other synthetic materials. During HD, blood is pumped into the top of the cartridge and distributed among these fibers. Simultaneously, dialysis fluid, known as dialysate, is introduced into the bottom of the cartridge, bathing the outside of the fibers. Across the semipermeable membrane,...
Extracorporeal Removal of Drugs: Peritoneal Dialysis and Hemodialysis
Patients with end-stage renal disease (ESRD) or those experiencing drug overdose often require extracorporeal methods to eliminate accumulated drugs and metabolites. Hemoperfusion, hemofiltration, and dialysis are the primary techniques to rapidly remove harmful substances without disrupting the patient's fluid and electrolyte balance. For those with compromised renal function, dosage adjustments of concurrent medications may be necessary during extracorporeal drug removal.Dialysis is a process...
Hemodialysis III: Nursing Management
The nursing management of a patient undergoing hemodialysis includes several critical steps, starting with a thorough assessment before the procedure.Before the Hemodialysis ProcedureFirst, record the patient's vital signs—blood pressure, heart rate, respiratory rate, and temperature—to establish a baseline. This baseline is essential for detecting conditions such as hypotension that could impact the patient's response to dialysis. Document the patient's pre-dialysis weight, as this measurement...
