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Related Experiment Video

Updated: Jul 5, 2026

Design of Cecal Ligation and Puncture and Intranasal Infection Dual Model of Sepsis-Induced Immunosuppression

Design of Cecal Ligation and Puncture and Intranasal Infection Dual Model of Sepsis-Induced Immunosuppression

Published on: June 15, 2019

New therapies for sepsis.

Aubrey Cunnington¹, Simon Nadel

¹Paediatric Intensive Care Unit, St Mary's NHS Trust and Imperial College, London, Praed Street London W2 1NY, UK.

Current Topics in Medicinal Chemistry

|May 14, 2008

Summary

Sepsis treatment focuses on simple interventions like antibiotics and oxygen delivery. While new experimental therapies show promise, demonstrating their efficacy in clinical trials remains a challenge.

Area of Science:

Critical Care Medicine
Infectious Diseases
Pharmacology

Background:

Sepsis is a significant cause of mortality with increasing incidence.
Despite numerous developed therapies, few demonstrate significant benefit in clinical trials.

Purpose of the Study:

To review current effective therapies for severe sepsis.
To explore emerging experimental treatments and their potential.
To highlight challenges in clinical trial efficacy demonstration.

Main Methods:

Review of existing clinical interventions for sepsis.
Analysis of experimental therapeutic strategies.
Discussion of challenges in clinical trial design and interpretation.

Main Results:

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Use of Animal Model of Sepsis to Evaluate Novel Herbal Therapies

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Cecal Ligation Puncture Procedure

Published on: May 7, 2011

Related Experiment Videos

Last Updated: Jul 5, 2026

Design of Cecal Ligation and Puncture and Intranasal Infection Dual Model of Sepsis-Induced Immunosuppression

Design of Cecal Ligation and Puncture and Intranasal Infection Dual Model of Sepsis-Induced Immunosuppression

Published on: June 15, 2019

Use of Animal Model of Sepsis to Evaluate Novel Herbal Therapies

Use of Animal Model of Sepsis to Evaluate Novel Herbal Therapies

Published on: April 11, 2012

Cecal Ligation Puncture Procedure

Cecal Ligation Puncture Procedure

Published on: May 7, 2011

Established therapies include antibiotics, goal-directed therapy, hydrocortisone, insulin therapy, and lung-protective ventilation.
Activated Protein C is the only adjunctive therapy with strong evidence of benefit.
Emerging strategies target inflammation neutralization, signal transduction, immune reconstitution, and statin use.

Conclusions:

Current successful sepsis management relies on fundamental clinical interventions.
Experimental therapies targeting molecular pathways show promise but require further validation.
Overcoming fundamental difficulties in clinical trials is crucial for advancing sepsis treatment.