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Related Concept Videos

Nephrotic Syndrome I : Introduction01:24

Nephrotic Syndrome I : Introduction

Nephrotic Syndrome is a chronic kidney disorder defined by clinical findings such as severe proteinuria, hypoalbuminemia, hyperlipidemia, and edema. These symptoms result from damage to the glomeruli, the kidney’s filtering units, increasing their permeability to proteins.Definition and Meaning:Proteinuria, defined as the loss of more than 3.5 grams of protein per day in adults, is a crucial feature of nephrotic syndrome. This condition is often accompanied by edema, the accumulation of fluid...
Nephrotic Syndrome II : Assessment and Medical Management01:26

Nephrotic Syndrome II : Assessment and Medical Management

IntroductionNephrotic syndrome is a kidney disorder marked by excessive protein loss in the urine, leading to various systemic complications. This condition often results from damage to the glomeruli—the kidney's filtering units—causing proteinuria, low blood protein levels, and fluid retention. Understanding the assessment, diagnosis, and management of nephrotic syndrome is essential for effective treatment and prevention of further kidney damage.AssessmentPatient History: Document any history...
Nephrotic Syndrome III : Nursing Management01:24

Nephrotic Syndrome III : Nursing Management

Nursing management for nephrotic syndrome adapts as the disease progresses, with strategies evolving to address advancing symptoms and complications.Early-Stage Management In the early stages, nursing interventions for nephrotic syndrome resemble those used in managing acute glomerulonephritis, focusing on symptom monitoring, fluid balance, and managing mild to moderate edema.Vital Signs: Regularly monitor blood pressure, pulse, respiratory rate, and temperature to promptly identify...
Chronic Kidney Disease II: Clinical Manifestations01:24

Chronic Kidney Disease II: Clinical Manifestations

Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...
Renal Corpuscle01:20

Renal Corpuscle

The glomerulus and Bowman's capsule are two essential components of the nephron, which is the functional unit of the kidney. These microscopic structures play a critical role in the process of blood filtration to produce urine.
Glomerulus: Structure and Function
The glomerulus is a tiny, intricate network of capillaries located at the beginning of the nephron. It's enveloped by the Bowman's capsule and receives its blood supply from an afferent arteriole, which divides into numerous capillaries...
Chronic Kidney Disease III: Interprofessional Care01:28

Chronic Kidney Disease III: Interprofessional Care

Chronic kidney disease (CKD) requires collaborative and comprehensive management. CKD progresses through stages and can lead to end-stage kidney disease (ESKD) if untreated. Interprofessional collaboration and patient education are crucial, enabling patients to manage their health and improve their quality of life.Diagnostic approach for chronic kidney diseaseThe diagnosis of CKD primarily focuses on the glomerular filtration rate (GFR), which assesses kidney function by measuring how well...

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Updated: Jul 5, 2026

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
04:44

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease

Published on: June 16, 2020

Scleroderma with crescentic glomerulonephritis: a case report.

Arunachalam Ramaswami1, Thiraviam Kandaswamy, Tholappan Rajendran

  • 1Department of Nephrology, RIPAS Hospital, Bander Seri Begawan, Brunei Darussalam. ramsdr@yahoo.com

Journal of Medical Case Reports
|May 14, 2008
PubMed
Summary
This summary is machine-generated.

Systemic sclerosis can cause rare kidney conditions like crescentic glomerulonephritis, distinct from scleroderma renal crisis. Early investigation is crucial for appropriate treatment of these alternative renal pathologies.

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Last Updated: Jul 5, 2026

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
04:44

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease

Published on: June 16, 2020

Area of Science:

  • Nephrology
  • Rheumatology
  • Autoimmune Diseases

Background:

  • Systemic sclerosis is an autoimmune disease causing organ fibrosis.
  • Renal involvement, typically scleroderma renal crisis, affects 5-10% of patients.
  • Other rare renal pathologies can occur, necessitating distinct diagnostic and treatment approaches.

Purpose of the Study:

  • To report a rare case of crescentic glomerulonephritis in a patient with systemic sclerosis.
  • To highlight the importance of investigating alternative renal pathologies beyond scleroderma renal crisis.

Main Methods:

  • Case report of a 52-year-old woman with systemic sclerosis and declining renal function.
  • Renal biopsy revealing immune complex crescentic glomerulonephritis.
  • Assessment of anti-neutrophil cytoplasmic antibodies (ANCA).

Main Results:

  • The patient presented with rapid renal function decline.
  • Kidney biopsy confirmed immune complex crescentic glomerulonephritis.
  • Despite immunosuppressive therapy, the patient progressed to end-stage renal failure requiring hemodialysis.

Conclusions:

  • Scleroderma renal crisis is the most common renal complication, but other pathologies exist.
  • Crescentic glomerulonephritis is a rare but serious renal manifestation of systemic sclerosis.
  • Suspecting and investigating alternative renal pathologies is vital for appropriate patient management.