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Related Concept Videos

Spinal Nerves: Plexus I01:22

Spinal Nerves: Plexus I

Nerve plexuses are networks of interlacing nerves that serve as communication hubs to distribute and organize nerve action across various body regions. The nerve plexuses are organized into the cervical plexus located in the neck region, brachial plexus in the shoulder area, lumbar plexus found in the lower back, sacral plexus situated in the pelvis, and coccygeal plexus located in the coccygeal region.
The Cervical Plexus
The cervical plexus, formed by the anterior rami of the first four...

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Related Experiment Video

Updated: Jul 6, 2026

Identifying, Diagnosing, and Grading Malignant Peripheral Nerve Sheath Tumors in Genetically Engineered Mouse Models
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Identifying, Diagnosing, and Grading Malignant Peripheral Nerve Sheath Tumors in Genetically Engineered Mouse Models

Published on: May 17, 2024

Adult-onset multifocal retroperitoneal plexiform neurofibromas: a case report.

Mehdi Ghaderian Jahromi1, Farima Safari2, Ali Nabavi3

  • 1Medical Imaging Research Center, Department of Radiology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.

Journal of Medical Case Reports
|July 4, 2026
PubMed
Summary

This case highlights rare adult-onset, multifocal plexiform neurofibromas in the retroperitoneum, emphasizing the diagnostic challenges of atypical presentations in patients without neurofibromatosis type 1.

Keywords:
Case reportNeurofibromatosis type 1Plexiform neurofibromasRetroperitoneal tumors

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An Orthotopic Sciatic Nerve Xenograft for Neurofibromatosis Type 1 Neurofibromas
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Identifying, Diagnosing, and Grading Malignant Peripheral Nerve Sheath Tumors in Genetically Engineered Mouse Models
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Identifying, Diagnosing, and Grading Malignant Peripheral Nerve Sheath Tumors in Genetically Engineered Mouse Models

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An Orthotopic Sciatic Nerve Xenograft for Neurofibromatosis Type 1 Neurofibromas
03:53

An Orthotopic Sciatic Nerve Xenograft for Neurofibromatosis Type 1 Neurofibromas

Published on: October 10, 2025

Area of Science:

  • Oncology
  • Radiology
  • Genetics

Background:

  • Plexiform neurofibromas are typically childhood tumors associated with neurofibromatosis type 1.
  • They usually present as diffuse, infiltrative masses within a single nerve.
  • Adult-onset, multifocal, discrete retroperitoneal plexiform neurofibromas are exceptionally rare.

Purpose of the Study:

  • To describe an unusual case of adult-onset, multifocal plexiform neurofibromas.
  • To expand the understanding of the phenotypic spectrum of these tumors.
  • To emphasize diagnostic challenges in atypical presentations.

Main Methods:

  • A 37-year-old woman presented with abdominal pain and anemia.
  • Imaging studies including ultrasonography, CT, and MRI were performed.
  • The patient had no prior diagnosis of neurofibromatosis type 1.

Main Results:

  • Imaging revealed multiple well-defined retroperitoneal soft tissue masses causing ureteral compression.
  • MRI demonstrated characteristic features suggestive of plexiform neurofibromas.
  • No evidence of neurofibromatosis type 1-related complications was found.

Conclusions:

  • This case represents a rare adult-onset, multifocal presentation of retroperitoneal plexiform neurofibromas.
  • Atypical imaging and clinical features necessitate heightened awareness to prevent misdiagnosis.
  • Multimodality imaging is crucial for identifying rare variants and understanding phenotypic variability.