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Updated: Jul 5, 2026
09:02
A Large Animal Model for Acute Kidney Injury by Temporary Bilateral Renal Artery Occlusion
Published on: February 2, 2021
Evidence-based renal replacement therapy for acute kidney injury
A Zarbock1, K Singbartl, J A Kellum
1Department of Anesthesiology and Intensive Care Medicine, University of Münster, Münster, Germany.
Minerva Anestesiologica
|May 14, 2008
Summary
Acute kidney injury (AKI) impacts critically-ill patients, often requiring renal replacement therapy (RRT). This review examines current data on RRT use in AKI management, highlighting ongoing controversies.
Area of Science:
- Nephrology
- Critical Care Medicine
Background:
- Acute kidney injury (AKI) affects 4-5% of critically-ill patients.
- AKI is linked to high mortality (60%) and morbidity.
- AKI independently predicts poor patient prognosis.
Purpose of the Study:
- To review and discuss current data on renal replacement therapy (RRT) for critically-ill patients with AKI.
- To address the controversies surrounding RRT initiation, modality, and dosage in AKI.
Main Methods:
- Literature review of available data on RRT in critically-ill AKI patients.
- Discussion of current evidence and ongoing clinical trials.
Main Results:
- AKI necessitates RRT in a significant portion of critically-ill patients.
- Various RRT methods exist, including continuous veno-venous hemofiltration and intermittent hemodialysis.
- Optimal timing, modality, and dose of RRT remain subjects of debate.
Conclusions:
- Effective management of AKI in critically-ill patients is crucial.
- RRT is a key treatment for AKI complications.
- Further research and clinical trials are needed to resolve RRT controversies in AKI.
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