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Updated: Oct 4, 2025
06:01
A Thrombotic Stroke Model Based On Transient Cerebral Hypoxia-ischemia
Published on: August 18, 2015
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Hemorrhagic Transformation Rates following Contrast Media Administration in Patients Hospitalized with Ischemic
F G Moser1, T M Todoran2, M Ryan3
1From the Department of Imaging (F.G.M.), Cedars-Sinai Medical Center, Los Angeles, California Franklin.Moser@cshs.org.
AJNR. American Journal of Neuroradiology
|February 11, 2022
Summary
Iso-osmolar contrast media significantly reduced the risk of hemorrhagic transformation after ischemic stroke compared to low-osmolar contrast media. This finding is particularly relevant for patients undergoing endovascular thrombectomy.
Area of Science:
- Neurology
- Radiology
- Cardiovascular Medicine
Background:
- Hemorrhagic transformation is a serious complication of ischemic stroke.
- Contrast media administration has been linked to this complication.
Purpose of the Study:
- To evaluate the correlation between contrast media type and the development of hemorrhagic transformation in ischemic stroke patients.
- Utilize real-world in-hospital data for this analysis.
Main Methods:
- Retrospective analysis of inpatient admissions for ischemic stroke.
- Inclusion of patients who received either iso-osmolar or low-osmolar iodinated contrast media for stroke-related procedures.
- Multivariable regression analysis adjusting for patient characteristics, comorbidities, procedure type, contrast volume, and hospital variations.
Main Results:
- Iso-osmolar contrast media was associated with a 1.4% absolute risk reduction in hemorrhagic transformation (P=.032) compared to low-osmolar media.
- A relative risk reduction of 12.5% was observed with iso-osmolar media.
- In patients undergoing endovascular thrombectomy, iso-osmolar media showed a significant absolute risk reduction of 4.6% (P=.028).
Conclusions:
- Iso-osmolar contrast media is associated with a lower incidence of hemorrhagic transformation in ischemic stroke patients.
- The findings suggest a potential benefit of using iso-osmolar contrast media to mitigate this complication.
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