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Updated: Jul 5, 2026

Myeloid Innate Signaling Pathway Regulation by MALT1 Paracaspase Activity
Published on: January 7, 2019
Cytokine gene regulation by PGE(2), LTB(4) and PAF
M Rola-Pleszczynski1, J Stankova
1Immunology Division Department of Pediatrics Faculty of Medicine University of Sherbrooke Sherbrooke QC J1H 5N4 Canada.
Abstract:
The initial response of the host to noxious stimuli produces a nonspecific inflammatory response. A more specific immune response is believed to be modulated by two classes of molecules: lipid mediators (PG, LT and PAF) and cytokines, synthesized by phagocytes and parenchyreal cells. In this review we discuss the increasing evidence of the interrelationship between eicosanoids, PAF and cytokines: IL-1 and TNF induce PG synthesis in various cells and PG, in turn, modulate cytokine production. We focused on the regulatory effects of LTB(4), PGE(2) and PAF on cytokine gene expression.
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