Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Clinical Trials

Clinical Trials

Clinical trials are prospective experimental studies conducted on humans to determine the safety and efficacy of treatments, drugs, diet methods, and medical devices. Using statistics in clinical trials enables researchers to derive reasonable and accurate conclusions from the collected data, allowing them to make wise decisions in uncertain situations. In medical research, statistical methods are crucial for preventing errors and bias.
There are four phases in a clinical trial. A phase one...

Clinical Trials: Overview

Clinical Trials: Overview

Clinical development focuses on how the drug will interact with the human body and encompasses four key phases of clinical trials, each serving a specific purpose in assessing the safety and effectiveness of new drugs. These phases overlap and build upon one another. Phase I involves a small group of healthy volunteers (typically 20-80 individuals) or, in cases where significant toxicity is expected, patients with the targeted disease, such as cancer or AIDS. The volunteers are tested for...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

The removal of caesium ions using supported clinoptilolite.

Journal of hazardous materials·2015

Same author

Immunotherapy for canine cancer--is it time to go back to the future?

The Journal of small animal practice·2015

Same author

Oesophageal foreign body: an unusual presentation.

The Journal of laryngology and otology·2013

Same author

e-Infrastructures supporting research into depression, self-harm and suicide.

Philosophical transactions. Series A, Mathematical, physical, and engineering sciences·2010

Same author

An analysis of listening skills of healthcare students in Nigeria.

West African journal of medicine·2010

Same author

The European disorder of sex development registry: a virtual research environment.

Sexual development : genetics, molecular biology, evolution, endocrinology, embryology, and pathology of sex determination and differentiation·2010

Search research articles

Related Experiment Video

Updated: Jul 5, 2026

A Video Protocol of a Randomized Controlled Clinical Trial - Electrochemotherapy of Cutaneous Metastases with Reduced Dose Bleomycin (BLESS Trial)

A Video Protocol of a Randomized Controlled Clinical Trial - Electrochemotherapy of Cutaneous Metastases with Reduced Dose Bleomycin (BLESS Trial)

Published on: June 9, 2026

Supporting grid-based clinical trials in Scotland.

R O Sinnott¹, A J Stell, O Ajayi

¹National e-Science Centre, University of Glasgow, Glasgow, UK. r.sinnott@nesc.gla.ac.uk

Health Informatics Journal

|May 15, 2008

Summary

Developing a secure, flexible computational infrastructure is crucial for clinical trials and population studies. This project explored challenges in accessing and using distributed clinical data dynamically for research.

More Related Videos

In Silico Clinical Trials for Cardiovascular Disease

In Silico Clinical Trials for Cardiovascular Disease

Published on: May 27, 2022

Individualized Stem-positioning in Calcar-guided Short-stem Total Hip Arthroplasty

Individualized Stem-positioning in Calcar-guided Short-stem Total Hip Arthroplasty

Published on: February 27, 2018

Related Experiment Videos

Last Updated: Jul 5, 2026

A Video Protocol of a Randomized Controlled Clinical Trial - Electrochemotherapy of Cutaneous Metastases with Reduced Dose Bleomycin (BLESS Trial)

A Video Protocol of a Randomized Controlled Clinical Trial - Electrochemotherapy of Cutaneous Metastases with Reduced Dose Bleomycin (BLESS Trial)

Published on: June 9, 2026

In Silico Clinical Trials for Cardiovascular Disease

In Silico Clinical Trials for Cardiovascular Disease

Published on: May 27, 2022

Individualized Stem-positioning in Calcar-guided Short-stem Total Hip Arthroplasty

Individualized Stem-positioning in Calcar-guided Short-stem Total Hip Arthroplasty

Published on: February 27, 2018

Area of Science:

Health Informatics
Clinical Trial Management
Population Health Studies

Background:

Complex clinical trials and population studies require robust computational infrastructure.
Existing systems often lack flexibility and security for distributed clinical datasets.
Need for reusable frameworks to accommodate diverse trial-specific data requirements.

Purpose of the Study:

To present experiences in developing a national computational infrastructure for trials and epidemiological studies.
To address challenges in accessing and utilizing distributed clinical datasets securely and flexibly.
To explore the creation of a reusable framework for complex medical research.

Main Methods:

Development of the Scottish component of the Virtual Organisations for Trials and Epidemiological Studies (VOTES) infrastructure.
Focus on creating a flexible, dynamic, and secure system for accessing and processing clinical data.
Collaboration between the National e-Science Centre (NeSC) and UK universities.

Main Results:

Identified key issues in accessing and using distributed clinical datasets.
Demonstrated the feasibility of developing a flexible and secure data access framework.
Highlighted the advantages of a reusable infrastructure for diverse research needs.

Conclusions:

A secure and flexible computational infrastructure is essential for advancing clinical trials and population studies.
The VOTES project provides valuable insights into building such systems.
Addressing data access and security challenges is critical for dynamic and efficient medical research.