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Related Concept Videos

Allergic Reactions02:06

Allergic Reactions

Overview
Allergic Reactions: Anaphylaxis01:30

Allergic Reactions: Anaphylaxis

Anaphylaxis is a severe, life-threatening hypersensitivity reaction mediated by Immunoglobulin E (IgE) antibodies. When IgE binds to allergens, it triggers the release of mediators– histamine, leukotrienes, and prostaglandins from mast cells and basophils. These mediators cause vasodilation, edema, and inflammation, leading to various symptoms.The primary allergens causing anaphylaxis include food items (e.g., peanuts, shellfish), drugs (e.g., penicillin, asparaginase, corticotropin, heparin),...
Drug Toxicity: Allergic Reactions01:30

Drug Toxicity: Allergic Reactions

Drug-related allergies are immune-mediated responses triggered by the administration of pharmacological agents. These hypersensitivity reactions are classified based on the immune mechanisms involved. The four primary types—Type I, II, III, and IV—are mediated by different immunological pathways and exhibit distinct clinical manifestations.Type I Hypersensitivity/ IgE-Mediated Reactions: Immunoglobulin E (IgE) immediately mediates Type I hypersensitivity reactions. Upon initial exposure to a...
Allergic Drug Reactions01:27

Allergic Drug Reactions

Allergic reactions related to drugs are hypersensitivity responses driven by the immune system and bear no connection to the drug's therapeutic action. While drugs in isolation do not trigger an immune response, they can interact with endogenous proteins to form antigens. These antigens stimulate lymphocytes to produce antibodies. IgE-type antibodies attach themselves to mast cells. Upon subsequent exposure to the same stimulus, the antigen-antibody interaction is initiated, unleashing numerous...
Hypersensitivities01:30

Hypersensitivities

Hypersensitivity, also known as a hypersensitivity reaction or allergic reaction, is a condition where the body's immune system reacts abnormally to a foreign substance. Such substances, that cause hypersensitivity are referred to as an allergen, could be something typically harmless to most people, like pollen or certain foods.
Types of Hypersensitivities
Hypersensitivity reactions are categorized into four types: Type 1, Type 2, Type 3, and Type 4. Each type has a distinct mechanism...
Cross-reactivity00:42

Cross-reactivity

Overview

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Related Experiment Video

Updated: Jul 5, 2026

A Mouse Ear Model for Allergic Contact Dermatitis Evaluation
08:02

A Mouse Ear Model for Allergic Contact Dermatitis Evaluation

Published on: March 24, 2023

Filaggrin mutations and allergic contact sensitization.

Jon M Hanifin1

  • 1Department of Dermatology, Oregon Health and Science University, Center for Health and Healing, Portland, Oregon 97239, USA. hanifinj@ohsu.edu

The Journal of Investigative Dermatology
|May 15, 2008
PubMed
Summary

Filaggrin barrier defects may increase susceptibility to allergic contact dermatitis by enhancing the skin

Area of Science:

  • Dermatology
  • Immunology
  • Genetics

Background:

  • Filaggrin is a key protein in the skin barrier.
  • Defects in filaggrin are associated with skin barrier dysfunction.
  • Allergic contact dermatitis is a common skin condition.

Purpose of the Study:

  • To investigate the role of filaggrin barrier defects in allergic contact dermatitis.
  • To explore the mechanism by which filaggrin defects may lead to sensitization.

Main Methods:

  • The study by Novak et al. (2008) is cited.
  • The report focuses on the implications of filaggrin barrier defects.

Main Results:

  • Filaggrin barrier defects may predispose individuals to allergic contact dermatitis.

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Contact Hypersensitivity as a Murine Model of Allergic Contact Dermatitis

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Last Updated: Jul 5, 2026

A Mouse Ear Model for Allergic Contact Dermatitis Evaluation
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Removal and Replacement of Endogenous Ligands from Lipid-Bound Proteins and Allergens
09:09

Removal and Replacement of Endogenous Ligands from Lipid-Bound Proteins and Allergens

Published on: February 24, 2021

Contact Hypersensitivity as a Murine Model of Allergic Contact Dermatitis
08:25

Contact Hypersensitivity as a Murine Model of Allergic Contact Dermatitis

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  • These defects allow greater penetration of chemical haptens into the skin.

    • Conclusions:

    • Filaggrin barrier defects represent a potential risk factor for allergic contact dermatitis.
    • Understanding these defects offers new insights into contact allergy and nickel sensitization.