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Synthesis and Regulation of Thyroid Hormones01:20

Synthesis and Regulation of Thyroid Hormones

Low blood levels of the thyroid hormones — triiodothyronine (T3) and thyroxine (T4) — signal the hypothalamus to release the thyrotropin-releasing hormone (TRH). TRH then reaches the pituitary gland and stimulates the release of thyroid-stimulating hormone(TSH) into the bloodstream.
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The iodine is then...
The Thyroid Gland01:23

The Thyroid Gland

The thyroid gland is a small, butterfly-shaped gland located in the neck and covers the anterior surface of the trachea. The gland has two lateral lobes connected by a thin tissue mass called the isthmus. Internally, each lobe comprises many small spherical structures known as thyroid follicles, surrounded by a network of blood vessels.
The follicles have a central cavity lined by simple cuboidal to squamous epithelial cells called follicular cells. These cells produce the glycoprotein...
Functions of Thyroid Hormones01:18

Functions of Thyroid Hormones

The thyroid hormone (TH) plays a pivotal role in the intricate orchestration of physiological processes, exerting profound effects on development, metabolism, and homeostasis throughout different life stages.
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Hyperthyroidism II: Pathophysiology01:27

Hyperthyroidism II: Pathophysiology

Hyperthyroidism is a hypermetabolic state caused by elevated levels of thyroid hormones, triiodothyronine (T3) and thyroxine (T4). It results from dysregulation at the thyroid, pituitary, or immune system level and affects multiple organ systems.PathophysiologyThe most common cause of hyperthyroidism is Graves’ disease, an autoimmune disorder in which antibodies, specifically thyroid-stimulating antibodies (TSAb), a subtype of TSH receptor antibodies (TRAb), bind to and activate TSH receptors...
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Kidney Transplant II: Surgical Procedure

Preoperative ManagementThe primary goals of preoperative management in kidney transplantation are to optimize the patient’s metabolic state and prepare them for surgery through diet adjustments, necessary dialysis, and tailored medical treatment. This phase also involves comprehensive infection screening and patient education about the surgical procedure and postoperative care to improve outcomes and adherence.Medical ManagementA comprehensive evaluation is required for both the living donor...
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Hyperthyroidism I: Introduction

Hyperthyroidism is a type of thyrotoxicosis characterized by the thyroid gland's overproduction of the thyroid hormones triiodothyronine (T3) and thyroxine (T4). This hormone excess increases the basal metabolic rate and enhances sensitivity to catecholamines.DiagnosisDiagnosis is based on clinical features and biochemical testing. It typically shows suppressed thyroid-stimulating hormone (TSH) levels below 0.4 mIU/L, with elevated free T3 and/or T4. Additional tests, including thyroid...

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Minimal Invasive Resection of Large Retrosternal Thyroid Goiter
04:09

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Published on: September 20, 2024

Is timing important in thyroid reoperation?

Yeşim Erbil1, Alp Bozbora, Evin Ademoglu

  • 1Department of General Surgery, Istanbul Medical Faculty, Istanbul University, Istanbul, Turkey. yerbil2003@yahoo.com

Journal of Otolaryngology - Head & Neck Surgery = Le Journal D'Oto-Rhino-Laryngologie Et De Chirurgie Cervico-Faciale
|May 16, 2008
PubMed
Summary

Performing completion thyroidectomy 90 days after initial surgery is beneficial. This timing reduces complications like hypoparathyroidism and allows for more extensive thyroid tissue removal compared to earlier reoperation.

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Area of Science:

  • Endocrinology
  • Surgical Oncology
  • Thyroid Surgery

Background:

  • Optimal timing for completion thyroidectomy after initial thyroid surgery remains unclear.
  • Current recommendations lack consensus on the ideal interval for reoperation.

Purpose of the Study:

  • To compare postoperative complications, residual tissue, and hormone levels after completion thyroidectomy at different time intervals.
  • To evaluate the impact of timing on outcomes in patients with thyroid carcinoma.

Main Methods:

  • Retrospective study of 60 patients with thyroid carcinoma post-bilateral subtotal thyroidectomy.
  • Group 1: Completion thyroidectomy within 90 days (n=29).
  • Group 2: Completion thyroidectomy after 90 days (n=31).

Main Results:

  • No significant difference in transient recurrent laryngeal nerve palsy incidence.
  • Significantly higher incidence of transient hypoparathyroidism in Group 1 (p < .001).
  • Greater thyroid tissue excision and reduction in thyroid volume, TSH, and Tg levels observed in Group 2.

Conclusions:

  • Completion thyroidectomy at 90 days post-initial operation is beneficial.
  • Delayed reoperation reduces complication incidence and allows for more complete tissue removal.
  • This timing is advantageous when immediate completion thyroidectomy is not feasible.