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Related Concept Videos

Allergic Drug Reactions01:27

Allergic Drug Reactions

Allergic reactions related to drugs are hypersensitivity responses driven by the immune system and bear no connection to the drug's therapeutic action. While drugs in isolation do not trigger an immune response, they can interact with endogenous proteins to form antigens. These antigens stimulate lymphocytes to produce antibodies. IgE-type antibodies attach themselves to mast cells. Upon subsequent exposure to the same stimulus, the antigen-antibody interaction is initiated, unleashing numerous...
Allergic Reactions: Anaphylaxis01:30

Allergic Reactions: Anaphylaxis

Anaphylaxis is a severe, life-threatening hypersensitivity reaction mediated by Immunoglobulin E (IgE) antibodies. When IgE binds to allergens, it triggers the release of mediators– histamine, leukotrienes, and prostaglandins from mast cells and basophils. These mediators cause vasodilation, edema, and inflammation, leading to various symptoms.The primary allergens causing anaphylaxis include food items (e.g., peanuts, shellfish), drugs (e.g., penicillin, asparaginase, corticotropin, heparin),...
Enzyme-Linked Immunosorbent Assay01:33

Enzyme-Linked Immunosorbent Assay

In 1971, Peter Perlman and Eva Engvall developed an Enzyme-linked immunosorbent assay (ELISA or EIA). ELISA differs from western blot in that the assays are conducted in microtiter plates or in vivo rather than on an absorbent membrane.
There are many different types of ELISAs, but they all involve an antibody molecule whose constant region binds an enzyme, leaving the variable region free to bind its specific antigen.  Enzyme-substrate reaction allows the antigen to be visualized or quantified.
Allergic Reactions02:06

Allergic Reactions

Overview
Antibody Structure01:10

Antibody Structure

Overview
Antibodies, also known as immunoglobulins (Ig), are essential players of the adaptive immune system. These antigen-binding proteins are produced by B cells and make up 20 percent of the total blood plasma by weight. In mammals, antibodies fall into five different classes, which each elicits a different biological response upon antigen binding.
The Y-Shaped Structure of Antibodies Consists of Four Polypeptide Chains
Antibodies consist of four polypeptide chains: two identical heavy...
Antigens Involved in Adaptive Immunity01:26

Antigens Involved in Adaptive Immunity

An antigen is any substance the immune system identifies as foreign and potentially harmful to the body, prompting an immune response. Antigens have two functional properties: immunogenicity and reactivity. Immunogenicity is the ability of an antigen to stimulate a specific immune response. At the same time, reactivity describes the antigen's ability to react with the cells and antibodies produced in response to it.
Complete Antigens
Complete antigens possess both immunogenicity and reactivity.

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Related Experiment Video

Updated: Jul 5, 2026

Application of Biochip Microfluidic Technology to Detect Serum Allergen-specific Immunoglobulin E (sIgE)
07:10

Application of Biochip Microfluidic Technology to Detect Serum Allergen-specific Immunoglobulin E (sIgE)

Published on: April 21, 2019

Efficient bibliographic searches on allergy using ISI databases.

J M Sáez Gómez1, J W Annan, J M Negro Alvarez

  • 1Department of Social and Health Sciences, University of Murcia Medical School, Spain. jmsaez@um.se

Allergologia Et Immunopathologia
|May 16, 2008
PubMed
Summary
This summary is machine-generated.

This guide introduces Thomson Reuters databases and Citation Indexes for publication analysis. Learn about the Impact Factor and Journal Citation Reports for assessing journal quality and indexing.

Related Experiment Videos

Last Updated: Jul 5, 2026

Application of Biochip Microfluidic Technology to Detect Serum Allergen-specific Immunoglobulin E (sIgE)
07:10

Application of Biochip Microfluidic Technology to Detect Serum Allergen-specific Immunoglobulin E (sIgE)

Published on: April 21, 2019

Area of Science:

  • Bibliometrics and scientometrics
  • Information science
  • Scholarly communication

Background:

  • Thomson Reuters databases, including Citation Indexes, are crucial for research analysis.
  • Understanding metrics like the Impact Factor is essential for evaluating publications.
  • Effective use of these databases requires knowledge of their search functionalities and analysis tools.

Purpose of the Study:

  • To introduce researchers to Thomson Reuters databases and Citation Indexes.
  • To explain the concept and application of the Impact Factor.
  • To guide users on utilizing Journal Citation Reports for bibliometric analysis.

Main Methods:

  • Overview of the Thomson ISI Web of Knowledge platform.
  • Explanation of search strategies within Citation Indexes.
  • Demonstration of the Journal Citation Reports and Impact Factor calculation.

Main Results:

  • The article details how to navigate and utilize Thomson Reuters databases for publication analysis.
  • It clarifies the meaning and calculation of the Impact Factor.
  • Guidance is provided on using these tools for journal assessment and indexing.

Conclusions:

  • Thomson Reuters databases and Citation Indexes are powerful tools for bibliometric analysis.
  • The Impact Factor, when used appropriately, can inform journal and publication assessment.
  • Understanding these resources aids in navigating scholarly communication and ensuring database indexing.