IRAK-4 inhibitors. Part II: a structure-based assessment of imidazo[1,2-a]pyridine binding
George M Buckley1, Thomas A Ceska, Joanne L Fraser
1UCB, Granta Park, Great Abington, Cambridge CB21 6GS, UK.
Abstract:
A potent IRAK-4 inhibitor was identified through routine project cross screening. The binding mode was inferred using a combination of in silico docking into an IRAK-4 homology model, surrogate crystal structure analysis and chemical analogue SAR.
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