Related Experiment Video
Updated: Jul 5, 2026

Metagenomic Next-Generation Sequencing of Cerebrospinal Fluid for the Detection of Central Nervous System Pathogens
Published on: April 17, 2026
[CNS infections in immunocompromised patients]
K M Hartmann1, M Golinski, W Reith
1Abt. für Diagnostische und Interventionelle Neuroradiologie, Radiologische Klinik, Universitätsklinikum des Saarlandes, 66421, Homburg/Saar. kirsten@hartmann-online.net
Abstract:
CNS infections caused by infective agents are rare in immunocompetent hosts, but more frequent in immunocompromised patients. In addition, the spectrum of causative agents is completely different. There are no pathognomonic alterations in radiologic imaging, even in clinically severely ill patients imaging is often non-specific or inconspicious. This article gives a review of the most frequent infective agents and image alterations. Modern radiology is not yet able to replace the gold standard of pathogen detection.
Related Concept Videos
Cryptococcal Meningitis
Immunodeficiency Diseases
There are three main causes of immunodeficiency disorders...
Encephalitis l: Introduction
Cytomegalovirus Disease
Encephalitis ll: Pathophysiology
Brain Abscess l: Introduction
