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Updated: Jul 5, 2026
03:13
Technical Refinement of a Bilateral Renal Ischemia-Reperfusion Mouse Model for Acute Kidney Injury Research
Published on: November 3, 2023
Surgical renal ischemia: a contemporary overview
Matthew N Simmons1, Martin J Schreiber, Inderbir S Gill
1Glickman Urological and Kidney Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA.
The Journal of Urology
|May 20, 2008
Summary
Warm ischemia during partial nephrectomy can harm kidney function. Current data suggest a 30-minute limit for patients with normal kidney function, but more research is needed to understand risks.
Area of Science:
- Nephrology
- Urology
- Surgical Research
Background:
- Partial nephrectomy is a common treatment for renal cell carcinoma.
- Warm ischemia is frequently induced during partial nephrectomy, raising concerns about kidney function.
- The impact of warm ischemia on postoperative renal outcomes requires further investigation.
Purpose of the Study:
- To review and assess the current knowledge on warm ischemic kidney injury.
- To evaluate the relationship between warm ischemia and renal functional outcomes after partial nephrectomy.
Main Methods:
- A comprehensive literature review was conducted from 1947 to 2007.
- Data from animal and clinical studies on warm ischemic kidney injury were analyzed and compared.
Main Results:
- Animal studies show a link between warm ischemia duration and renal dysfunction, but clinical applicability is limited.
- Clinical evidence suggests a safe warm ischemia time limit of 30 minutes for patients with normal preoperative kidney function.
- No robust clinical studies have established a dose-response curve for warm ischemia or predictive algorithms for kidney injury.
Conclusions:
- Improved diagnosis and reporting of renal outcomes may be achieved through glomerular filtration rate (GFR) measurements and kidney injury biomarkers.
- Prospective, controlled clinical studies are essential to precisely define the relationship between warm ischemia and renal dysfunction.
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