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The relationship between severity of coronary artery disease and plasma level of vascular endothelial growth factor

Yasar Kucukardali1, Sebnem Aydogdu, Namik Ozmen

  • 1Department of Internal Medicine, Gulhane School of Medicine, Haydarpasha Training Hospital, Istanbul, Turkey. yasarkardali@yahoo.com <yasarkardali@yahoo.com>

Cardiovascular Revascularization Medicine : Including Molecular Interventions
|May 20, 2008
PubMed

Insights

Elevated vascular endothelial growth factor (VEGF) in patients with coronary artery disease indicates critical blockages. Increased VEGF may signal the need for revascularization in these patients.

Area of Science:

  • Cardiovascular Medicine
  • Biochemistry

Background:

  • Coronary artery disease (CAD) is a significant health concern.
  • Vascular Endothelial Growth Factor (VEGF) is known to increase with coronary artery occlusion in animal models.
  • The relationship between VEGF and human CAD, particularly the degree of coronary occlusion, requires further investigation.

Purpose of the Study:

  • To investigate the correlation between the degree of coronary artery occlusion and plasma VEGF levels in patients with established CAD.
  • To assess the relationship between plasma VEGF and other cardiac risk factors.

Main Methods:

  • The study included 77 patients with established coronary artery disease.
  • Patients were categorized into a control group (normal angiography) and groups with abnormal angiography (critical and non-critical lesions).
  • Plasma VEGF levels were measured and compared across groups, with logistic regression analysis performed.

Main Results:

  • Plasma VEGF levels were significantly higher in patients with critical coronary lesions compared to controls.
  • A negative correlation was observed between VEGF and hemoglobin, and a positive correlation with age.
  • No significant relationship was found between plasma VEGF and other common cardiac risk parameters.

Conclusions:

  • Elevated plasma VEGF levels in CAD patients may indicate critical coronary lesions.
  • VEGF may serve as a potential biomarker for identifying patients who require revascularization.
Abstract

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