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[Cardiovascular effects of D-ALA2, LEU5, ARG6-enkephalin (dalargin) are mediated by peripheral mu-opioid receptor
Abstract:
It has been established that intravenous administration of dalargin at a dose of 0.1 mg/kg induced hypotensive, positive inotropic, and positive chronotropic response in patients with myocardial infarction, while not producing the "steal syndrome." The positive chronotropic effect of dalargin was mediated by peripheral mu-opioid receptors. Increase in the heart rate induced by dalargin had a reflex nature. Direct action of dalargin on the heart was accompanied by a decrease in the heart rate and a delay in the cardiac conductance in the atrioventricular junction region.
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