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Updated: Jul 5, 2026
Localization and Relative Quantification of Carbon Nanotubes in Cells with Multispectral Imaging Flow Cytometry
Published on: December 12, 2013
Label-free detection of sequence-specific DNA with multiwalled carbon nanotubes and their light scattering signals
Li Zhang1, Cheng Zhi Huang, Yuan Fang Li
1College of Chemistry and Chemical Engineering, MOE Key Laboratory of Luminescence and Real-Time Analysis, CQKL-LRTA, Southwest University, Chongqing, China.
Abstract:
A detection method for DNA sequence-specificity in a homogeneous medium is presented with multiwalled carbon nanotubes (MWCNTs) as optical probes on the basis of the measurements of light scattering signals. ssDNA can prevent MWCNTs from coagulation in electrolyte solution while dsDNA cannot, displaying different light scattering signals. With the light scattering signals, target DNA in the range of 8.6-86.4 nM could be detected and one base pair mismatch could be discriminated. The sequence specificity for the present method has been identified with PCR products.
