Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Mecobalamin.

Yi-Fei Zhang1, Guang Ning

  • 1Shanghai Institute of Endocrinology and Metabolism, Division of Endocrine and Metabolic Diseases of E-Institute of Shanghai Universities, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, PR China.

Expert Opinion on Investigational Drugs
|May 22, 2008
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

CRISPR-based modular assembly of a UAS-cDNA/ORF plasmid library for more than 5500 <i>Drosophila</i> genes conserved in humans.

Genome research·2019
Same author

A nomogram for predicting the presence of germline mutations in pheochromocytomas and paragangliomas.

Endocrine·2019
Same author

The Association between Resting Heart Rate and Urinary Albumin/Creatinine Ratio in Middle-Aged and Elderly Chinese Population: A Cross-Sectional Study.

Journal of diabetes research·2019
Same author

High-Coverage Targeted Lipidomics Reveals Novel Serum Lipid Predictors and Lipid Pathway Dysregulation Antecedent to Type 2 Diabetes Onset in Normoglycemic Chinese Adults.

Diabetes care·2019
Same author

Ideal Cardiovascular Health Metrics and Major Cardiovascular Events in Patients With Prediabetes and Diabetes.

JAMA cardiology·2019
Same author

Dual Effect of <i>Raptor</i> on Neonatal β-Cell Proliferation and Identity Maintenance.

Diabetes·2019
Same journal

Investigational new drug TAP-1502 beginning clinical study for seborrheic dermatitis.

Expert opinion on investigational drugs·2026
Same journal

Cannabinoid use in adults with sickle cell disease: therapeutic development and clinical insights.

Expert opinion on investigational drugs·2026
Same journal

Odronextamab: a bispecific antibody for follicular lymphoma.

Expert opinion on investigational drugs·2026
Same journal

Evaluating the investigational drug landscape for <i>ESR1</i>-mutated, estrogen receptor-positive, HER2-negative metastatic breast cancer.

Expert opinion on investigational drugs·2026
Same journal

Darigabat and subtype-selective GABA-A modulation: pharmacology, clinical development, and translational challenges.

Expert opinion on investigational drugs·2026
Same journal

Safety, tolerability, and pharmacokinetics of HL-300, a novel topical pan-JAK inhibitor, in healthy Chinese adults: a first-in-human, randomized, double-blind, placebo-controlled phase I trial.

Expert opinion on investigational drugs·2026
See all related articles

Mecobalamin effectively lowers homocysteine and improves neuropathy symptoms. Combined therapy with other B vitamins shows greater efficacy than mecobalamin alone, though further research is needed.

Area of Science:

  • Biochemistry
  • Pharmacology
  • Clinical Medicine

Background:

  • Mecobalamin, a vitamin B12 coenzyme, is crucial for methyltransferase activity.
  • It's primarily used for hyperhomocysteinemia and peripheral neuropathy.
  • A comprehensive review of its clinical use and mechanisms is lacking.

Purpose of the Study:

  • To review mecobalamin's mechanism of action.
  • To evaluate the clinical efficacy and safety of mecobalamin.
  • To assess its use in treating hyperhomocysteinemia and peripheral neuropathy.

Main Methods:

  • Clarified mecobalamin's mechanism, pharmacokinetics, and metabolism.
  • Detailed clinical administration, including efficacy, safety, and tolerability.
  • Examined mecobalamin as monotherapy and in combination therapies.

Related Experiment Videos

Main Results:

  • Both mecobalamin monotherapy and combined therapy reduce homocysteine levels.
  • Neuropathic symptoms show improvement with mecobalamin treatment.
  • Combined therapy with other B vitamins appears more effective.

Conclusions:

  • Mecobalamin is effective for hyperhomocysteinemia and peripheral neuropathy.
  • Combination therapy with B vitamins may enhance treatment outcomes.
  • Further rigorous studies are required to confirm efficacy and long-term effects.