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Related Concept Videos

Appendicitis01:19

Appendicitis

Appendicitis is an acute inflammatory condition of the vermiform appendix, most commonly caused by obstruction of its lumen. The appendix is a narrow, blind-ended pouch that extends from the cecum, making it particularly prone to obstruction. Causes include fecaliths, lymphoid hyperplasia (often after viral infections), parasites, tumors, or foreign bodies. This obstruction initiates a cascade of pathological changes.Luminal Obstruction and Early InflammationAfter obstruction, normal mucosal...
Appendicitis-I: Introduction01:22

Appendicitis-I: Introduction

The appendix, a small, narrow, blind tube extending from the inferior part of the cecum, is widely regarded as a vestigial organ, having lost much of its original function through evolution. Despite its diminished role, the appendix can become inflamed, a condition known as appendicitis.
Etiology: Appendicitis can arise from various causes, primarily rooted in the obstruction of the appendix lumen. Factors contributing to this obstruction include fecal accumulation, lymphoid hyperplasia and, in...
Appendicitis-II: Diagnostic Studies and Management01:29

Appendicitis-II: Diagnostic Studies and Management

Diagnosing and managing appendicitis requires a structured and comprehensive approach that spans from initial assessment to postoperative care. Here is an overview of the process:
Diagnosing Appendicitis
It requires a multifaceted approach, starting with a detailed physical examination to pinpoint the location and nature of the pain and identify any associated symptoms. Laboratory tests play a crucial role. A complete Blood Count (CBC) typically reveals leukocytosis (an increased number of...
Diverticular Disease of the Colon01:27

Diverticular Disease of the Colon

Diverticular disease involves the formation of diverticula—small sac-like outpouchings of the colonic wall—and their complications. It most commonly affects the sigmoid colon due to higher intraluminal pressure and structural vulnerability. It results from structural weakness and increased pressure in the colon, producing pseudodiverticula that may remain silent or progress to inflammation and serious complications.Structure of DiverticulaIn diverticulosis, these outpouchings are...
Cholecystitis01:20

Cholecystitis

Cholecystitis is inflammation of the gallbladder, most commonly caused by obstruction of the cystic duct. This blockage prevents bile from draining, leading to gallbladder distension, inflammation, and potentially serious complications. This condition may present acutely or chronically and can happen with or without gallstones.EtiologyAbout 95% of cholecystitis cases are calculous, caused by gallstones blocking the cystic duct, leading to bile accumulation and inflammation of the gallbladder...
Acute Pancreatitis I: Introduction01:25

Acute Pancreatitis I: Introduction

Acute pancreatitis is the sudden inflammation of the pancreas caused by the early activation of digestive enzymes, leading to the autodigestion of pancreatic tissue. This results in local inflammation and, in severe cases, systemic complications.EtiologyUnderstanding the underlying causes is crucial, as identifying the etiology guides treatment and anticipates complications. Acute pancreatitis can be triggered by various factors, typically grouped into the following clinical categories.Biliary...

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Related Experiment Video

Updated: Jul 5, 2026

Murine Appendectomy Model of Chronic Colitis Associated Colorectal Cancer by Precise Localization of Caecal Patch
08:51

Murine Appendectomy Model of Chronic Colitis Associated Colorectal Cancer by Precise Localization of Caecal Patch

Published on: August 24, 2019

Acute appendicitis--a benign disease?

J Simpson1, A Pr Samaraweera, R K Sara

  • 1Division of Gastrointestinal Surgery, Wolfson Digestive Disease Centre, Nottingham University Hospitals, Queen's Medical Centre, Nottingham, UK. j.simpson@nottingham.ac.uk

Annals of the Royal College of Surgeons of England
|May 22, 2008
PubMed
Summary
This summary is machine-generated.

Appendectomy (surgical removal of the appendix) can lead to complications, with septic issues more common in inflamed appendices. However, patients with a normal appendix removed are more likely to be readmitted for pain.

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Area of Science:

  • Surgery
  • Gastroenterology
  • Clinical Medicine

Background:

  • Appendicitis is a common cause of acute abdominal pain across all age groups.
  • While most patients recover well after appendectomy, some experience postoperative complications.
  • This study reviews complication rates following emergency appendectomies.

Purpose of the Study:

  • To determine the frequency of postoperative complications after emergency appendectomy.
  • To compare complication rates between patients with confirmed appendicitis and those with a negative appendectomy.

Main Methods:

  • Retrospective review of adult patients (>16 years) undergoing emergency appendectomy.
  • Data collected included operative details, histology, and postoperative complications.
  • 199 patients were identified from pathology records between February 2004 and January 2005.

Main Results:

  • 58% of patients experienced postoperative complications.
  • Septic complications were more frequent in patients with confirmed appendicitis (18% vs 3%).
  • Patients with a negative appendectomy had higher readmission rates (34% vs 8.5%), primarily for persistent abdominal pain.

Conclusions:

  • Appendectomy is associated with significant morbidity.
  • While inflamed appendices lead to more septic complications, normal appendices removed result in higher readmissions due to pain.
  • Risk stratification and pain management are crucial post-appendectomy.