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Enabling methodology for the end functionalization of glycosaminoglycan oligosaccharides

Emiliano Gemma1, Odile Meyer, Dusan Uhrín

  • 1School of Chemistry, The University of Edinburgh, Kings Buildings, West Mains Road, Edinburgh, UK.

Molecular Biosystems
|May 22, 2008
PubMed

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Glycans, a class of complex heterogeneous molecules, can be covalently attached to proteins to form glycosylated proteins that regulate various physiological and pathological processes. Glycosylated proteins or glycoproteins comprise N-linked and O-linked oligosaccharides. O-glycosylation is the most common type of protein glycosylation. Here, glycans attach to the oxygen atom of the hydroxyl groups of Serine or Threonine residues. O-linked glycosylation occurs later in protein processing,...
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Glycosaminoglycans (GAGs), also known as mucopolysaccharides, are long and linear polymers comprising of specific repeating disaccharides - the amino sugar that can be N-acetylglucosamine or N-acetylgalactosamine, and a uronic acid that is usually glucuronic acid or iduronic acid.
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