Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

The Retinoblastoma Gene

The Retinoblastoma Gene

Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

CIRSE Standards of Practice for the Classification of Complications: The Modified CIRSE Classification System.

Cardiovascular and interventional radiology·2025

Same author

[Individual and contextual factors associated with violent behaviours during psychiatric hospitalizations].

L'Encephale·2021

Same author

[Three clinical risk profiles of violent behavior in a cohort of early psychosis patients].

L'Encephale·2018

Same author

[Pain therapy for children and adolescents with hemophilia : Recommendations by an expert panel].

Schmerz (Berlin, Germany)·2018

Same author

[Inflammatory gastrointestinal diseases in children : Radiological diagnosis].

Der Radiologe·2018

Same author

Impulsivity in early psychosis: A complex link with violent behaviour and a target for intervention.

European psychiatry : the journal of the Association of European Psychiatrists·2018

Search research articles

Related Experiment Video

Updated: Jul 5, 2026

Establishment of Orthotopic Patient-derived Xenograft Models for Brain Tumors using a Stereotaxic Device

Establishment of Orthotopic Patient-derived Xenograft Models for Brain Tumors using a Stereotaxic Device

Published on: May 2, 2025

[Brain tumors in childhood].

M Sinzig¹, J Gasser, B Jauk

¹Kinderradiologie RZI , Landeskrankenhaus Klagenfurt, Klagenfurt, Osterreich. Maria.Sinzig@lkh-klu.at

|May 22, 2008

Summary

Pediatric central nervous system (CNS) tumors vary by age and location. This review details common childhood brain tumors and their neuroradiological features for accurate diagnosis.

Area of Science:

Pediatric oncology
Neuroradiology
Central nervous system (CNS) neoplasms

Background:

Central nervous system (CNS) tumors are the most frequent solid tumors in children and the second most common pediatric malignancy.
Tumor incidence varies with age: supratentorial tumors are common in very young children and adolescents, while posterior fossa tumors dominate in mid-childhood.
This age- and location-dependent distribution is crucial for differential diagnosis.

Purpose of the Study:

To discuss typical central nervous system (CNS) neoplasms encountered in pediatric patients.
To illustrate the neuroradiological features of these common childhood brain tumors.

Main Methods:

Review of typical pediatric central nervous system (CNS) neoplasms.
Demonstration of neuroradiological characteristics.

More Related Videos

Processing of Primary Brain Tumor Tissue for Stem Cell Assays and Flow Sorting

Processing of Primary Brain Tumor Tissue for Stem Cell Assays and Flow Sorting

Published on: September 25, 2012

Transposon Mediated Integration of Plasmid DNA into the Subventricular Zone of Neonatal Mice to Generate Novel Models of Glioblastoma

Transposon Mediated Integration of Plasmid DNA into the Subventricular Zone of Neonatal Mice to Generate Novel Models of Glioblastoma

Published on: February 22, 2015

Related Experiment Videos

Last Updated: Jul 5, 2026

Establishment of Orthotopic Patient-derived Xenograft Models for Brain Tumors using a Stereotaxic Device

Establishment of Orthotopic Patient-derived Xenograft Models for Brain Tumors using a Stereotaxic Device

Published on: May 2, 2025

Processing of Primary Brain Tumor Tissue for Stem Cell Assays and Flow Sorting

Processing of Primary Brain Tumor Tissue for Stem Cell Assays and Flow Sorting

Published on: September 25, 2012

Transposon Mediated Integration of Plasmid DNA into the Subventricular Zone of Neonatal Mice to Generate Novel Models of Glioblastoma

Transposon Mediated Integration of Plasmid DNA into the Subventricular Zone of Neonatal Mice to Generate Novel Models of Glioblastoma

Published on: February 22, 2015

Main Results:

Medulloblastoma is the most common malignant pediatric brain tumor.
In the posterior fossa, medulloblastomas and astrocytomas occur with similar frequency.
Supratentorial astrocytomas are the predominant tumor type in this location.

Conclusions:

Understanding the relationship between tumor type, location, and patient age is essential for diagnosing pediatric CNS tumors.
Neuroradiological features are key to identifying and differentiating common childhood brain tumors.