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Published on: July 12, 2011
Vascular thrombosis associated with antiphospholipide syndrome
Marija Glasnović1, Ivica Bosnjak, Aleksandar Vcev
1Department of Internal Medicine, School of Medicine, University J. J. Strossmayer, Osijek, Croatia. glasnovic.marija@kbo.hr
Collegium Antropologicum
|May 23, 2008
Summary
This study details diagnostic and therapeutic strategies for antiphospholipid syndrome (APS) and vascular thrombosis in 99 patients. Findings highlight antibody prevalence and effective anticoagulation management using heparin and warfarin.
Area of Science:
- Rheumatology
- Hematology
- Immunology
Background:
- Antiphospholipid syndrome (APS) is an autoimmune disorder associated with aPL antibodies and an increased risk of thrombosis.
- Distinguishing between primary APS (PAPS) and secondary APS (SAPS) is crucial for management.
- Vascular thrombosis is a major complication of APS, necessitating effective diagnostic and therapeutic approaches.
Purpose of the Study:
- To present diagnostic and therapeutic experiences with antiphospholipid syndrome (APS) and vascular thrombosis.
- To analyze the prevalence of antiphospholipid antibodies (aPL) in patients with primary and secondary APS.
- To evaluate the efficacy of anticoagulation therapy in patients with APS and vascular thrombosis.
Main Methods:
- Retrospective analysis of 99 patients with positive aPL and vascular thrombosis.
- Classification of patients into primary APS (PAPS) and secondary APS (SAPS) groups.
- Assessment of antibody positivity (LA, IgG aCL, IgM aCL, IgG anti-beta2GPI) and therapeutic interventions.
Main Results:
- In the PAPS group, high positivity rates for LA (82.5%), IgG aCL (37.5%), and IgM aCL (27.5%) were observed.
- In the SAPS group, LA (61%), IgG aCL (50.8%), and IgM aCL (47.5%) positivity were also significant.
- Therapy involved initial low molecular weight heparin (LMWH) followed by warfarin, maintaining INR between 2.0-3.0.
Conclusions:
- The study provides valuable insights into the clinical presentation and serological profiles of APS patients with vascular thrombosis.
- The described therapeutic regimen of LMWH followed by warfarin demonstrates a practical approach to anticoagulation management.
- Further research may explore optimal long-term anticoagulation strategies and risk stratification in APS.
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