THE ASSOCIATION OF SYNTAX SCORE II WITH LIPID PROFILE, SERUM URIC ACID LEVELS AND DIABETES MELLITUS IN PATIENTS WITH...

Area of Science:

• Cardiology
• Clinical Risk Assessment

Background:

• The SYNTAX Score II (SS II) is a validated tool for predicting mortality in patients with multivessel coronary artery disease (CAD).
• Understanding factors influencing SS II is crucial for optimizing treatment strategies, including percutaneous coronary intervention (PCI) and coronary artery bypass grafting (CABG).

Purpose of the Study:

• To investigate the correlation between lipid profiles (HDL, LDL, total cholesterol, triglycerides), uric acid levels, and diabetes status with SS II values in CAD patients.
• To determine if traditional atherosclerosis risk factors are associated with higher SS II scores.

Main Methods:

• A cohort of 72 CAD patients was analyzed.
• SS II was calculated using an online calculator.
• Statistical analyses, including Mann Whitney U and Shapiro-Wilk tests, were employed to assess correlations between clinical parameters and SS II.

Main Results:

• A significant positive correlation was observed between high HDL levels and SS II for PCI.
• Lower LDL levels were associated with increased SS II for CABG.
• Hyperuricemia and diabetes status showed a significant positive correlation with SS II for PCI.
• No significant correlation was found for total cholesterol and triglycerides with either SS II PCI or SS II CABG.

Conclusions:

• SS II is associated with established atherosclerosis risk factors like diabetes and hyperuricemia.
• Unexpectedly, the study found correlations between SS II and lipid profiles, specifically high HDL and low LDL levels in this patient cohort.
• These findings suggest a complex interplay of factors influencing SS II and highlight the need for further research.