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THE ASSOCIATION OF SYNTAX SCORE II WITH LIPID PROFILE, SERUM URIC ACID LEVELS AND DIABETES MELLITUS IN PATIENTS WITH

Vedran Đambić1, Ivica Bošnjak2, Dijana Dumančić

  • 1Hyperbaric Medicine Unit, Slavonia Polyclinic, Osijek, Croatia.

Acta Clinica Croatica
|February 4, 2026
PubMed

Insights

The SYNTAX Score II (SS II) predicts mortality in multivessel coronary artery disease (CAD). Higher SS II scores correlate with diabetes and hyperuricemia, but surprisingly also with high HDL and low LDL levels.

Area of Science:

  • Cardiology
  • Clinical Risk Assessment

Background:

  • The SYNTAX Score II (SS II) is a validated tool for predicting mortality in patients with multivessel coronary artery disease (CAD).
  • Understanding factors influencing SS II is crucial for optimizing treatment strategies, including percutaneous coronary intervention (PCI) and coronary artery bypass grafting (CABG).

Purpose of the Study:

  • To investigate the correlation between lipid profiles (HDL, LDL, total cholesterol, triglycerides), uric acid levels, and diabetes status with SS II values in CAD patients.
  • To determine if traditional atherosclerosis risk factors are associated with higher SS II scores.

Main Methods:

  • A cohort of 72 CAD patients was analyzed.
  • SS II was calculated using an online calculator.
  • Statistical analyses, including Mann Whitney U and Shapiro-Wilk tests, were employed to assess correlations between clinical parameters and SS II.

Main Results:

  • A significant positive correlation was observed between high HDL levels and SS II for PCI.
  • Lower LDL levels were associated with increased SS II for CABG.
  • Hyperuricemia and diabetes status showed a significant positive correlation with SS II for PCI.
  • No significant correlation was found for total cholesterol and triglycerides with either SS II PCI or SS II CABG.

Conclusions:

  • SS II is associated with established atherosclerosis risk factors like diabetes and hyperuricemia.
  • Unexpectedly, the study found correlations between SS II and lipid profiles, specifically high HDL and low LDL levels in this patient cohort.
  • These findings suggest a complex interplay of factors influencing SS II and highlight the need for further research.

Keywords:
Diabetes mellitusHyperuricemiaLipid profileMultivessel coronary diseaseSYNTAX Score II

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