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Related Experiment Video

Updated: Jul 5, 2026

Double Direct Injection of Blood into the Cisterna Magna as a Model of Subarachnoid Hemorrhage

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Microemboli in aneurysmal subarachnoid hemorrhage.

Jose G Romano¹, Alejandro A Rabinstein, Kristopher L Arheart

¹Department of Neurology, University of Miami, Miami, FL, USA. jromano@med.miami.edu

Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging

|May 23, 2008

Summary

Microemboli, detected as embolic signals (ES), are a significant risk factor for cerebral ischemia in subarachnoid hemorrhage (SAH) patients, independent of vasospasm. Early detection of ES can aid in predicting ischemic complications.

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Last Updated: Jul 5, 2026

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Published on: August 30, 2020

Pre-Chiasmatic, Single Injection of Autologous Blood to Induce Experimental Subarachnoid Hemorrhage in a Rat Model

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Published on: June 18, 2021

Endovascular Perforation Model for Subarachnoid Hemorrhage Combined with Magnetic Resonance Imaging (MRI)

Endovascular Perforation Model for Subarachnoid Hemorrhage Combined with Magnetic Resonance Imaging (MRI)

Published on: December 16, 2021

Area of Science:

Neurology
Neurosurgery
Critical Care Medicine

Background:

Subarachnoid hemorrhage (SAH) poses significant risks for ischemic complications.
The precise determinants of SAH-related cerebral ischemia remain incompletely understood.

Purpose of the Study:

To investigate the role of microemboli in the development of cerebral ischemia following aneurysmal SAH.
To evaluate the association between embolic signals (ES) and ischemic complications.

Main Methods:

Transcranial Doppler (TCD) was used to monitor 40 aneurysmal SAH patients for embolic signals (ES) and vasospasm.
Clinical follow-up assessed for cerebral ischemic symptoms up to 14 days post-hemorrhage.

Main Results:

Microembolic signals (ES) were detected in 15/40 patients, appearing around 6.7 days post-hemorrhage.
A strong association was found between ES and cerebral ischemic symptoms (P=.003).
Ultrasonographic vasospasm did not correlate with ischemia, and ES were independent of vasospasm.

Conclusions:

Embolic signals (ES) are detected in over a third of SAH patients.
ES are significantly associated with the development of cerebral ischemic symptoms.
ES represent an independent risk factor for ischemic symptoms in SAH, separate from vasospasm.