Related Experiment Video
Updated: Jul 5, 2026

Behavioral Disturbances: An Innovative Approach to Monitor the Modulatory Effects of a Nutraceutical Diet
Published on: January 3, 2017
Effect of residence time on the efficacy of antidandruff shampoos
C Piérard-Franchimont1, E Uhoda, G Loussouarn
1Department of Dermatopathology, University Hospital Sart Tilman, B-4000 Liège, Belgium.
Abstract:
Dandruff is known to be controlled by fungistatic shampoos active against Malassezia spp. These products also remove the loosely attached scales. This study was performed to assess the effect of a 5-min residence time on the efficacy of antidandruff shampoos. Two commercially available shampoos were used in two groups of 21 panelists with severe dandruff. They contained either 1% ketoconazole or 1% piroctone olamine. In each group, intraindividual comparisons were made by a split-scalp design between the effect of a 5-min residence time versus no residence time. Both shampoos induced significant reductions in scaliness and yeast colonization. The beneficial effects were obvious immediately after one single shampooing and 3 days later as well. The improvement was greater with a 5-min residence time. The piroctone olamine treatment benefited more than the ketoconazole treatment from the extension of shampoo-exposure time. In conclusion, the benefit of a residence time in treating dandruff is documented. The level of improvement in efficacy may vary according to the nature of the shampoo.
More Related Videos
Related Concept Videos
Pharmacokinetic–Pharmacodynamic Relationship: Duration of Dose-Effect Relationship
Antimicrobial Effectiveness
Pharmacokinetic–Pharmacodynamic Relationship: Influence of Elimination Half-Life on Effect Duration
Factors Affecting Dissolution: Particle Size and Effective Surface Area
Noncompartmental Analysis: Mean Transit, Absorption and Dissolution Time
One of the key parameters is the mean transit time (MTT), which refers to the total duration required for drug molecules to transit through the body. MTT is determined by calculating the ratio of the area under the moment curve to the area...
Noncompartmental Analysis: Mean Residence Time
After the administration of a drug through intravenous bolus injection, the drug molecules are distributed throughout the body and remain there for varying periods. The MRT represents the average time these drug molecules stay in the...

