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Updated: Jul 5, 2026
Intracavernosal Pressure Recording to Evaluate Erectile Function in Rodents
Published on: June 6, 2018
[Establishment of a rat model of diabetic erectile dysfunction]
Yi Cheng1, An-yang Wei, Yu-gang Li
1Huiqiao Department, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China. chengyipla@sina.com
Objective:
To establish a rat model of diabetic erectile dysfunction (ED) with streptozotocin (STZ) injection.
Methods:
Thirty male rats were randomized equally into 5 groups (control group and STZ 40 mg/kg, 60 mg/kg, 80 mg/kg, and 100 mg/kg groups). All the rats were examined at 4 days and 1, 2, and 3 weeks after STZ injection for fasting blood glucose, erectile frequency induced by apomorpHine (APO) and body weight changes.
Results:
Significant difference occurred in the fasting food glucose among the groups at different time points (P=0.001), and also in APO-induced erectile frequency, fasting blood glucose and body weight between the groups with STZ injection at different doses (P<0.001, P=0.045 and P<0.001, respectively). No significant difference was found in induced erectile frequency and body weight between different time points (P=0.306 and P=0.628).
Conclusion:
The optimal dose of STZ for establishing diabetic ED model is 60 mg/kg, and two weeks after the injection can be the optimal time for evaluating model establishment by means of APO-induced penis erection.
