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Related Concept Videos

Drug Dosing in Renal Diseases: Estimation of Glomerular Filtration Rate Based on Serum Creatinine Concentration01:28

Drug Dosing in Renal Diseases: Estimation of Glomerular Filtration Rate Based on Serum Creatinine Concentration

Glomerular filtration rate (GFR) can be estimated from serum creatinine using the modification of diet in renal disease (MDRD) formula or the chronic kidney disease–epidemiology collaboration (CKD–EPI) equation. Both methods are widely used in clinical practice to assess kidney function and guide treatment decisions.The MDRD equation does not require weight or height measurements and is normalized to the body surface area of 1.73 m², considered the average adult surface area. This equation is...
Chronic Kidney Disease I: Introduction01:25

Chronic Kidney Disease I: Introduction

Chronic Kidney Disease (CKD) arises when the kidneys progressively lose their ability to function, ultimately leading to end-stage renal disease. At this advanced stage, the kidneys can no longer filter waste or maintain essential body functions, requiring renal replacement therapy (RRT) through dialysis or a kidney transplant for survival.Early-stage chronic kidney disease and detection challengesIn CKD's early stages, symptoms often remain absent because healthy nephrons compensate for...
Chronic Kidney Disease III: Interprofessional Care01:28

Chronic Kidney Disease III: Interprofessional Care

Chronic kidney disease (CKD) requires collaborative and comprehensive management. CKD progresses through stages and can lead to end-stage kidney disease (ESKD) if untreated. Interprofessional collaboration and patient education are crucial, enabling patients to manage their health and improve their quality of life.Diagnostic approach for chronic kidney diseaseThe diagnosis of CKD primarily focuses on the glomerular filtration rate (GFR), which assesses kidney function by measuring how well...
Chronic Kidney Disease II: Clinical Manifestations01:24

Chronic Kidney Disease II: Clinical Manifestations

Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...
Chronic Kidney Disease IV: Nursing Management01:18

Chronic Kidney Disease IV: Nursing Management

Nursing management is essential for preventing complications, maintaining stability, and improving patients' quality of life in chronic kidney disease (CKD). By using a structured approach, nurses help slow CKD progression and support effective patient care​.1. Comprehensive patient assessmentEffective management begins with nurses reviewing the patient’s medical history, and identifying key risk factors like diabetes, hypertension, and nephrotoxic drug use. Nurses assess signs of fluid...
Drug Dosing: Obese Patients01:21

Drug Dosing: Obese Patients

In the United States, obesity is a prominent concern. It is linked to heightened mortality rates due to increased occurrences of conditions such as hypertension, atherosclerosis, coronary artery disease, and diabetes compared to nonobese individuals. A patient is classified as obese if their actual body weight surpasses the ideal or desirable body weight by 20%, based on Metropolitan Life Insurance Company data. Ideal body weights consider average weights and heights for males and females...

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Related Experiment Videos

Changes in body weight predict CKD in healthy men.

Seungho Ryu1, Yoosoo Chang, Hee-Yeon Woo

  • 1Department of Occupational Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University, School of Medicine, Seoul, Korea 110-746. sh703.yoo@samsung.com

Journal of the American Society of Nephrology : JASN
|May 23, 2008
PubMed
Summary

Weight gain increases chronic kidney disease (CKD) risk, even within a normal body mass index (BMI). This study found a U-shaped association, with the lowest CKD risk seen in those with minimal weight change.

Related Experiment Videos

Area of Science:

  • Nephrology
  • Metabolic Health
  • Epidemiology

Background:

  • Obesity is a known risk factor for chronic kidney disease (CKD).
  • The impact of weight gain on CKD risk within the normal body mass index (BMI) range is not well understood.

Purpose of the Study:

  • To investigate the association between weight change and the incidence of CKD in men with no prior CKD risk factors.
  • To determine if weight gain contributes to CKD risk even when BMI remains within the normal range.

Main Methods:

  • Prospective cohort study of 8792 healthy men.
  • Follow-up over 35,927 person-years, with 427 incident CKD cases identified (eGFR <64 ml/min per 1.73 m²).
  • Cox proportional hazards modeling used to analyze weight change and CKD incidence, with adjustments for multiple risk factors.

Main Results:

  • A U-shaped association was observed between weight change and CKD risk in both normal-weight and overweight groups.
  • The lowest CKD risk was associated with a weight change between -0.25 and 0.25 kg/year.
  • Weight gain independently predicted increased CKD risk, even when maintaining a normal BMI.

Conclusions:

  • Increases in body weight are independently associated with a higher risk of developing chronic kidney disease.
  • Weight management is crucial for kidney health, irrespective of maintaining a normal body mass index.