A randomized trial of unruptured brain arteriovenous malformations (ARUBA)

Despite almost a century of efforts in the treatment of brain arteriovenous malformations (BAVMs) no clinical trial has yet been performed to demonstrate the benefits of intervention versus conservative (medical) management for those not yet bled. Only insufficient information on the natural history of unbled BAVMs exists to certify that intervention is needed and that such intervention produces a better long-term functional outcome.