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Updated: Jul 5, 2026

A 3D Organotypic Melanoma Spheroid Skin Model
Published on: May 18, 2018
Long-term survival in stage IV melanoma after repetitive surgical therapy
Tsvetomir Tomov1, Robert Siegel, Andreas Bembenek
1Klinik fur Chirurgie und Chirurgische Onkologie, Robert-Rossle-Klinik, Campus Buch im Helios-Klinikum, Charité Universitatsmedizin Berlin, Germany.
Background:
Surgical therapy in patients with stage IV melanoma is controversial and always an individual decision.
Case Report:
We report the case of a young melanoma patient, who underwent resection of 5 distant metastases from 4 different organ systems. Thereby, the patient achieved a stable state of disease and a good quality of life for up to now 67 months without any evidence for further tumor manifestations at present. A systemic chemo- or immunotherapy was never applied.
Conclusion:
In selected patients with stage IV melanoma, surgery alone can provide long-term survival with good quality of life.

