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Related Experiment Video

Updated: Jul 5, 2026

Three-Dimensional Cell Culture Models to Investigate the Epithelial Barrier in Eosinophilic Esophagitis

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Eosinophilic gastroenteritis.

Seema Khan¹, Susan R Orenstein

¹Thomas Jefferson University Medical School, Division of Pediatric Gastroenterology and Nutrition, Alfred I. DuPont Hospital for Children, Wilmington, DE 19803, USA. sekhan@nemours.org

Gastroenterology Clinics of North America

|May 24, 2008

Summary

This summary is machine-generated.

Eosinophilic gastroenteritis involves eosinophil buildup in the stomach or small intestine, often linked to allergies. Diagnosis requires high suspicion and confirmation of gastrointestinal eosinophilia.

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Area of Science:

Gastroenterology
Immunology
Allergy

Background:

Eosinophilic gastroenteritis is a rare condition.
Characterized by eosinophilic infiltration of the stomach or small intestine.
Presents with variable clinical manifestations due to diverse organ involvement and wall depth.

Purpose of the Study:

To define eosinophilic gastroenteritis.
To highlight diagnostic challenges and criteria.
To review current and emerging treatment strategies.

Main Methods:

Diagnosis relies on identifying significant gastrointestinal eosinophilia.
Association with atopy is frequently observed.
Th-2 proinflammatory cytokine profiles support the role of immune responses in animal models.

Main Results:

Heterogeneous clinical presentations are common.
Strong association with atopy is noted.
Intense gastrointestinal eosinophilia is the diagnostic hallmark.

Conclusions:

Eosinophilic gastroenteritis requires a high index of suspicion for diagnosis.
Management involves allergen avoidance and anti-inflammatory drugs.
Biologic therapies and targeted anti-eosinophil agents represent future treatment avenues.