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Sex hormone binding globulin decrease as a potential pathogenetic factor for hirsutism in adolescent girls.

Graciela Cross1, Karina Danilowicz, Martha Kral

  • 1División de Endocrinología, Hospital de Clínicas, Facultad de Medicina, Universidad de Buenos Aires, Argentina.

Medicina
|May 27, 2008
PubMed
Summary
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An exaggerated decrease in sex hormone binding globulin (SHBG) during adolescence and increased free testosterone (FT) in adulthood may contribute to hirsutism development in women.

Area of Science:

  • Endocrinology
  • Reproductive Health
  • Dermatology

Background:

  • Hirsutism, characterized by excess male-pattern hair growth in women, has complex etiologies.
  • The role of sex hormone binding globulin (SHBG) and free testosterone (FT) in adolescent hirsutism development requires further elucidation.

Purpose of the Study:

  • To investigate the relationship between SHBG levels, FT levels, and hirsutism development in non-obese females aged 13-39 years.
  • To determine if altered SHBG and FT levels during adolescence predict later hirsutism.

Main Methods:

  • A cohort of 252 non-obese females aged 13-39 years was studied.
  • Body hair was assessed using the Ferriman-Gallwey (FG) score.
  • Serum SHBG and FT levels were measured and correlated with FG scores across different age groups.

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Main Results:

  • In adolescent girls (15-18 years), lower SHBG levels correlated inversely with hirsutism (FG score).
  • In adult women (19-39 years), higher FT levels correlated positively with hirsutism.
  • The rate of SHBG decrease during adolescence and FT increase with age was more pronounced in the hirsute group.

Conclusions:

  • Adolescent SHBG decline plays a role in early hirsutism development.
  • Increased adult FT levels are associated with hirsutism in later life.
  • These hormonal changes during different life stages are critical factors in hirsutism pathogenesis.