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Rous Sarcoma Virus (RSV) and Cancer

Rous Sarcoma Virus (RSV) and Cancer

Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...

Rous Sarcoma Virus (RSV) and Cancer

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Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...

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Related Experiment Video

Updated: Jul 5, 2026

Generation of a Novel Dendritic-cell Vaccine Using Melanoma and Squamous Cancer Stem Cells

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Published on: January 6, 2014

Follicular dendritic cell sarcoma: a case report.

Ciğdem Tokyol¹, Mustafa Deniz Yilmaz, Ozlem Ekici

¹Department of Pathology, Afyon Kocatepe University School of Medicine, Afyon, Turkey. ctokyol@yahoo.com

Acta Cytologica

|May 27, 2008

Summary

This summary is machine-generated.

Follicular dendritic cell (FDC) sarcoma, a rare cancer, presents unique fine needle aspiration (FNA) findings. Accurate diagnosis requires immunohistochemical stains to avoid underrecognition of this entity.

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Isolation and Characterization of Tumor-initiating Cells from Sarcoma Patient-derived Xenografts

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Published on: January 6, 2014

Isolation and Characterization of Tumor-initiating Cells from Sarcoma Patient-derived Xenografts

Isolation and Characterization of Tumor-initiating Cells from Sarcoma Patient-derived Xenografts

Published on: June 13, 2019

Area of Science:

Oncology
Pathology

Background:

Follicular dendritic cell (FDC) sarcoma is a rare neoplasm.
It originates from follicular dendritic cells and can occur in nodal and extranodal locations.

Observation:

A case of FDC sarcoma in a 41-year-old woman presenting as a neck mass is described.
Fine needle aspiration (FNA) was performed, revealing a malignant tumor.
Microscopic examination showed a lymph node largely replaced by oval to spindle cells with CD21 immunopositivity.

Findings:

FDC sarcoma exhibits characteristic FNA cytomorphology.
Immunohistochemical staining, particularly for CD21, is crucial for definitive diagnosis.
The tumor recurred locally two years after initial excision.

Implications:

Characteristic FNA findings can suggest FDC sarcoma.
Awareness of this rare tumor is essential for timely and accurate diagnosis.
Immunohistochemistry is vital for differentiating FDC sarcoma from other malignancies.