Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Mouse segmental duplication and copy number variation.

Xinwei She1, Ze Cheng, Sebastian Zöllner

  • 1Department of Genome Sciences, University of Washington, 1705 NE Pacific Street, Seattle, Washington 98195, USA.

Nature Genetics
|May 27, 2008
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Structurally divergent and recurrently mutated regions of primate genomes.

bioRxiv : the preprint server for biology·2023
Same author

TAD Evolutionary and functional characterization reveals diversity in mammalian TAD boundary properties and function.

bioRxiv : the preprint server for biology·2023
Same author

Genetic Ablation of GIGYF1, Associated With Autism, Causes Behavioral and Neurodevelopmental Defects in Zebrafish and Mice.

Biological psychiatry·2023
Same author

Telomere-to-telomere assembly of diploid chromosomes with Verkko.

Nature biotechnology·2023
Same author

Structural variation across 138,134 samples in the TOPMed consortium.

Research square·2023
Same author

Structural variation across 138,134 samples in the TOPMed consortium.

bioRxiv : the preprint server for biology·2023
Same journal

Lineage tracing from cellular heritage to disease destiny.

Nature genetics·2026
Same journal

Multiomics analysis of primary metabolism reveals the genetic basis of nitrogen partitioning modulated by ZmAVT1A-1 in maize.

Nature genetics·2026
Same journal

No evidence of immunosurveillance in mutation-hotspot-driven clonal hematopoiesis.

Nature genetics·2026
Same journal

Near-perfect genome sequencing in medical genetics.

Nature genetics·2026
Same journal

Three decades of cancer genetics.

Nature genetics·2026
Same journal

Advances and challenges of splicing prediction with AI.

Nature genetics·2026
See all related articles

Mouse genome duplication content is similar to humans, but organized differently. Mouse strains exhibit significant copy number variation, particularly in gene families related to reproduction and immunity.

Area of Science:

  • Genomics
  • Comparative Genomics
  • Mammalian Genetics

Background:

  • Previous whole-genome shotgun sequence assemblies underestimated mouse genome duplication content.
  • Recent clone-based assembly provides a more accurate estimate of recent duplication.

Purpose of the Study:

  • To compare recent duplication content between mouse and human genomes.
  • To characterize the architecture and copy number variation (CNV) of duplicated regions in mouse genomes.
  • To assess interstrain CNV in 15 mouse strains.

Main Methods:

  • Detailed analysis of clone-based genome assembly.
  • Assessment of copy number variation in duplicated regions across 15 mouse strains.
  • Comparative analysis of mouse and human genome duplication.

Related Experiment Videos

Main Results:

  • Mouse recent duplication content (4.94%) is comparable to human (5.5%).
  • Mouse duplications are clustered tandem arrays, depleted of genes and enriched for retroposons (LINE, LTR).
  • Over 60% of duplicated base pairs are polymorphic among mouse strains, with significant interstrain CNV.

Conclusions:

  • Mouse and human genomes show similar recent duplication levels but distinct architectures.
  • Mouse strains exhibit substantial, locally restricted copy number polymorphism.
  • Interstrain CNV is concentrated in gene families involved in reproduction and immunity.