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Related Concept Videos

Development of the Lymphatic System01:15

Development of the Lymphatic System

The development of lymphatic tissues and vessels in embryonic life begins around the fifth week. These structures originate from the mesoderm layer, with lymph sacs emerging from developing veins.
The first lymph sacs to form are the paired jugular lymph sacs located at the junction of the internal jugular and subclavian veins. From these sacs, lymphatic capillary plexuses extend to the thorax, upper limbs, neck, and head, eventually forming lymphatic vessels. Each jugular lymph sac maintains a...
Lymphatic Vessels and Lymph Transport01:16

Lymphatic Vessels and Lymph Transport

Lymphatic vessels, known as lymphatics, are crucial in transporting lymph from peripheral tissues to our venous system. This process begins with lymph entering through tiny capillaries that branch through tissues. These capillaries have unique features such as larger diameters, thinner walls, and a distinctive one-way valve system formed by overlapping endothelial cells.
This one-way system allows fluids, solutes, and even pathogens to enter but prevents their return to the intercellular spaces.
Mechanism of Angiogenesis01:10

Mechanism of Angiogenesis

Blood vessel formation starts early during embryonic development, around day 7. In the extraembryonic yolk sac, mesodermal precursor cells called hemangioblast proliferate and differentiate into angioblast. Angioblasts express vascular endothelial growth factor receptor 2 or VEGFR2, which binds VEGF-A, a proangiogenic factor, guiding blood vessel formation. VEGF signaling promotes angioblasts to form a blood island in the developing embryo. Angioblasts further differentiate, giving rise to...
Regulation of Angiogenesis and Blood Supply01:24

Regulation of Angiogenesis and Blood Supply

Rapidly dividing tumors, embryos, and wounded tissues require more oxygen than usual, lowering the oxygen concentration in the blood. At low oxygen or hypoxic conditions, an oxygen-sensitive transcription factor called the hypoxia-inducible factor 1 or HIF1 is activated. HIF1 is a dimeric protein of alpha (ɑ) and beta (β) subunits.  Under optimal oxygen conditions, HIF1β is present in the nucleus while HIF1ɑ remains in the cytosol. HIF1ɑ is hydroxylated by prolyl hydroxylase and factor...
Detailed Structure and Function of Lymph Nodes01:23

Detailed Structure and Function of Lymph Nodes

Lymph nodes are bean-shaped structures that cluster along the lymphatic vessels in the inguinal, axillary, and cervical regions. Each node is divided into compartments by a capsule that extends trabeculae inward.
From a histological perspective, lymph nodes can be split into two main areas: the superficial cortex and the deep medulla. The outer cortex is populated by dendritic cells, macrophages, and B lymphocytes, which are densely packed into follicles. When these B-lymphocytes are presented...
Tumor Progression02:07

Tumor Progression

Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...

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Related Experiment Video

Updated: Jul 5, 2026

Isolation of Human Lymphatic Endothelial Cells by Multi-parameter Fluorescence-activated Cell Sorting
07:36

Isolation of Human Lymphatic Endothelial Cells by Multi-parameter Fluorescence-activated Cell Sorting

Published on: May 1, 2015

Pathogenesis of lymphangiomas.

Susanne Wiegand1, Behfar Eivazi, Peter J Barth

  • 1Department of Otolaryngology, Head and Neck Surgery, Philipps-University of Marburg, Deutschhausstr. 3, Marburg, Germany. swiegand@med.uni-marburg.de

Virchows Archiv : an International Journal of Pathology
|May 27, 2008
PubMed
Summary
This summary is machine-generated.

Lymphangioma development involves complex lymphangiogenesis, potentially stemming from vascular system malformations or acquired factors. Further research is needed to determine if lymphangiomas are developmental anomalies or neoplastic growths.

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Murine Dermal Lymphatic Endothelial Cell Isolation
05:52

Murine Dermal Lymphatic Endothelial Cell Isolation

Published on: July 21, 2023

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Last Updated: Jul 5, 2026

Isolation of Human Lymphatic Endothelial Cells by Multi-parameter Fluorescence-activated Cell Sorting
07:36

Isolation of Human Lymphatic Endothelial Cells by Multi-parameter Fluorescence-activated Cell Sorting

Published on: May 1, 2015

Murine Dermal Lymphatic Endothelial Cell Isolation
05:52

Murine Dermal Lymphatic Endothelial Cell Isolation

Published on: July 21, 2023

Area of Science:

  • Vascular Biology
  • Developmental Biology
  • Pathogenesis of Tumors

Background:

  • Lymphangiomas are congenital vascular malformations.
  • Their development is poorly understood, with multiple hypotheses proposed.
  • Existing theories involve lymphatic system development and acquired factors.

Purpose of the Study:

  • To review and discuss hypotheses on lymphangioma development.
  • To explore the role of lymphangiogenesis and growth factors.
  • To differentiate between malformative and neoplastic origins.

Main Methods:

  • Literature review of hypotheses on lymphangiogenesis.
  • Discussion of proposed mechanisms for lymphangioma development.
  • Analysis of the role of growth factors in pathogenesis.

Main Results:

  • Hypotheses include failures in lymphatic-venous connection/separation and abnormal budding.
  • Acquired factors like trauma, infection, and inflammation are also implicated.
  • Evidence suggests lymphangiogenic growth factors influence development.

Conclusions:

  • Lymphangioma pathogenesis is multifactorial, involving developmental and acquired processes.
  • The role of growth factors in lymphangioma endothelium is increasingly recognized.
  • Further studies are essential to classify lymphangiomas as malformations or neoplasms.