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Bioreactor Controls-II01:18

Bioreactor Controls-II

In aerobic fermentations, oxygen is vital for microbial growth and metabolite production. Since air comprises only about 20% oxygen and the gas is poorly soluble in water—just 9 ppm at 20°C—supplying sufficient oxygen becomes a critical challenge, especially in high-demand processes like yeast growth or citric acid production. Even a fully saturated broth may offer only a few seconds of oxygen availability.To address this, sterile or scrubbed air is introduced into the fermentor via a sparger...

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A Multilayer Microfluidic Platform for the Conduction of Prolonged Cell-Free Gene Expression
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Published on: October 6, 2019

Enhanced bio-molecular interactions through recirculating microflows.

A Chandrasekaran1, M Packirisamy

  • 1Concordia University, Optical Microsystems Laboratory, CONCAVE Research Center, Department of Mechanical Engineering, Montreal, Canada. achandra@alcor.concordia.ca

IET Nanobiotechnology
|May 27, 2008
PubMed
Summary
This summary is machine-generated.

A novel microfluidic platform enables optical bio-detection without immobilizing biological species. This system allows for rapid, in situ detection of biological pairs using fluorescence, enhancing biomedical diagnostics.

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Area of Science:

  • Biomedical Engineering
  • Microfluidics
  • Optical Biosensing

Background:

  • Microfluidic devices offer miniaturized platforms for biological analysis.
  • Efficient mixing and isolation of analytes are crucial for sensitive bio-detection.
  • Current methods often require analyte immobilization, limiting flexibility.

Purpose of the Study:

  • To develop a recirculating microfluidic platform for optical bio-detection.
  • To demonstrate passive mixing and analyte isolation without immobilization.
  • To validate the platform's capability for qualitative and quantitative bio-detection.

Main Methods:

  • Development of a recirculating microfluidic device with controlled flow.
  • Utilized fluorescence detection with Antisheep Antibody (AB) tagged with Alexafluor 647 (AF647).
  • Employed finite element modeling for flow behavior analysis and comparison with experimental results.

Main Results:

  • Demonstrated passive mixing and isolation of tagged antibodies within the microfluidic channel.
  • Achieved successful qualitative and quantitative bio-detection using fluorescence.
  • Flow visualization results closely matched finite element modeling predictions.

Conclusions:

  • The developed microfluidic platform facilitates efficient mixing and isolation of biological species.
  • The system is suitable for in situ, rapid, fluorescence-based biomedical detection.
  • This hybrid integrated device provides a reliable tool for detecting biological pairs or specimens.