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Updated: Jul 5, 2026
06:38
A Syngeneic Mouse Model of Metastatic Renal Cell Carcinoma for Quantitative and Longitudinal Assessment of Preclinical Therapies
Published on: April 12, 2017
[Neoadjuvant therapy for renal cancer]
F Thibault1, O Rixe, J-B Meric
1Service d'urologie, d'oncologie médicale de radiologie et de pathologie, hôpital de la Pitié-Salpêtrière, université Pierre-et-Marie-Curie, 47, boulevard de l'Hôpital, 75013 Paris, France. frederic.thibault@gmail.com
Summary
Sunitinib treatment significantly reduced large renal cell carcinoma and lymph node size, enabling successful nephrectomy. Histology confirmed extensive tumor necrosis post-treatment, indicating treatment efficacy.
Area of Science:
- Oncology
- Nephrology
- Pharmacology
Background:
- Renal cell carcinoma (RCC) presents challenges with large tumors and lymph node involvement.
- Sunitinib is a targeted therapy used for advanced renal cell carcinoma.
Observation:
- A 73-year-old male patient with large left kidney renal cell carcinoma and extensive lymph node extension received neoadjuvant sunitinib therapy for 10 months.
- Pre-operative imaging demonstrated substantial tumor and lymph node volume reduction after sunitinib treatment.
Findings:
- Histological examination post-nephrectomy revealed predominantly necrotic primary renal tumor.
- Lymph nodes also showed a significant degree of necrosis, though less pronounced than the primary tumor.
Implications:
- Neoadjuvant sunitinib can effectively debulk locally advanced renal cell carcinoma, facilitating surgical resection.
- This approach may improve outcomes for patients with initially unresectable RCC due to tumor burden.
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