A psychophysical study of human binocular interactions in normal and amblyopic visual systems

During infancy and childhood, spatial contrast sensitivity and alignment sensitivity undergo maturation, and during this period the visual system has considerable plasticity. The purpose of this study was to compare the nature of interocular interactions of these spatial functions in normally sighted children and adults, and to study the extent to which interocular interactions are impaired in anisometropic amblyopia. Spatial functions were measured under three viewing conditions: monocular (fellow eye occluded), dichoptic (uniform stimulus presented to the fellow eye but with a peripheral fusion lock), and binocular. Measurements were made in each eye during monocular and dichoptic viewing. In the contrast sensitivity task, Gabor stimuli were presented in one of two temporal intervals. For the alignment task, a three-element Gabor stimulus was used. The task of the subject was to indicate the direction of displacement of the middle patch with respect to the outer patches. The findings indicate that in children, binocular contrast sensitivity was better than monocular (binocular summation) but so too was dichoptic sensitivity (dichoptic summation). The magnitude of binocular/dichoptic summation was significantly greater in children than in normally sighted adults for contrast sensitivity, but not for alignment sensitivity. In anisometropic amblyopes, however, we find that for the group as a whole the amblyopic eye does not benefit when the fellow eye views a dichoptic stimulus, compared to dark occlusion of that eye. In addition, we found considerable inter-individual variation within the amblyopic group. Implications of these findings for techniques used in vision therapy are discussed.