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Flash NanoPrecipitation for the Encapsulation of Hydrophobic and Hydrophilic Compounds in Polymeric Nanoparticles
Published on: January 7, 2019
Micronization of gemfibrozil by reactive precipitation process.
Qiao-Ping Huang1, Jie-Xin Wang, Gui-Zhi Chen
1Sin-China Nano Technology Center, Key Lab for Nanomaterials, Ministry of Education, Beijing University of Chemical Technology, Beijing 100029, PR China.
International Journal of Pharmaceutics
|May 27, 2008
Summary
Ultrafine gemfibrozil (GEM) particles were synthesized using reactive precipitation. This method significantly improved GEM
Area of Science:
- Pharmaceutical Sciences
- Materials Science
Background:
- Gemfibrozil (GEM) is a lipid-regulating drug with poor aqueous solubility.
- Improving GEM's dissolution rate is crucial for enhancing its bioavailability.
Purpose of the Study:
- To develop a method for preparing ultrafine gemfibrozil (GEM) particles.
- To investigate the impact of process parameters on particle characteristics.
- To evaluate the effect of particle size reduction on GEM's dissolution properties.
Main Methods:
- Reactive precipitation using methyl cellulose (MC) as a growth inhibitor.
- Optimization of sodium hydroxide (NaOH) and sulfuric acid (H2SO4) concentrations.
- Characterization using SEM, XRD, FT-IR, BET surface area analysis, and dissolution testing.
Main Results:
- Ultrafine GEM particles with a mean size of 1.25 µm were successfully prepared.
- Specific surface area increased approximately sixfold compared to bulk GEM.
- Dissolution rate dramatically improved, with 91.2% dissolved in 120 min for ultrafine GEM versus 23.6% for bulk GEM.
Conclusions:
- The reactive precipitation method effectively produced ultrafine GEM with enhanced properties.
- Reduced particle size and increased surface area are key factors for improved GEM dissolution.
- This approach offers a promising strategy for enhancing the therapeutic efficacy of poorly soluble drugs like GEM.
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