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Updated: Jul 5, 2026

A 3D Organotypic Melanoma Spheroid Skin Model
Published on: May 18, 2018
[Melanoma of the oral mucosa]
1Service de stomatologie et chirurgie maxillo-faciale, CIU, hôpital Ambroise-Paré, université Libre de Bruxelles, 2, boulevard Kennedy, 7000 Mons, Belgique. michele.magremann@ulb.be
Introduction:
The oral melanoma (OM) account for 1% of all melanomas. The prognosis is poor despite an adequate locoregional control of the disease.
Clinical Case:
A 45-year-old woman presented with submandibular lymph nodes, having metastised from a melanoma. Oral cavity examination revealed a pigmented lesion of the gingiva in front of tooth 12, with satellite spots. Surgical treatment, radiotherapy, chemotherapy, and immunotherapy failed and the patient died 16 months after diagnosis.
Discussion:
Oral melanomas have a poor prognosis probably because they are generally detected late. The most common sites for oral melanomas are the palate and maxillary gingiva. About 30% of OM is preceded by areas of oral pigmentation for several months or years. The prognosis is poor with a 5% to 20% five-year survival rate.
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