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A Human Fallopian Tube Model for Investigation of C. trachomatis Infections
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Risk factors for active trachoma in The Gambia.

E M Harding-Esch1, T Edwards, A Sillah

  • 1London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK. emma.harding-esch@lshtm.ac.uk

Transactions of the Royal Society of Tropical Medicine and Hygiene
|May 27, 2008
PubMed
Summary

Active trachoma risk factors in Gambian children include age (1-5 years), nasal/ocular discharge, and household trachoma cases. Child-level interventions are needed, as household controls show effectiveness.

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Area of Science:

  • Ophthalmology
  • Infectious Diseases
  • Public Health

Background:

  • Trachoma remains endemic in The Gambia, despite falling prevalence.
  • Understanding risk factors is crucial for effective trachoma control strategies.

Purpose of the Study:

  • To investigate risk factors for active trachoma in children under 10 years old.
  • To assess ocular Chlamydia trachomatis infection prevalence.

Main Methods:

  • Cross-sectional study in two Gambian regions.
  • Analysis of active trachoma and C. trachomatis infection in children under 10.
  • Logistic regression for risk factor identification.

Main Results:

  • Active trachoma prevalence was 10.4%; C. trachomatis infection was 0.3%.
  • Risk factors for active trachoma included ages 1-5 years, nasal/ocular discharge, and co-infected household children.
  • Children of traders had a reduced risk of active trachoma.

Conclusions:

  • Household-level trachoma control interventions appear effective.
  • Child-level risk factors necessitate enhanced control efforts.
  • Targeting child-specific factors is key for future trachoma elimination.