Related Experiment Video
Updated: Jul 5, 2026
10:08
High-Resolution Respirometry in a Small-Volume Chamber
Published on: July 25, 2025
The SACD method and the XLRS squamometry tests revisited
C Piérard-Franchimont1, F Henry, G E Piérard
1Department of Dermatopathology, CHU Sart Tilman, B-4000 Liège, Belgium.
International Journal of Cosmetic Science
|May 28, 2008
Summary
Squamometry, a method using calibrated stripping with adhesive-coated discs (SACD), offers rapid, reliable, and cost-effective assessments of the stratum corneum. Various squamometry indices evaluate skin conditions like xerosis, UV damage, renewal, and surfactant effects.
Area of Science:
- Dermatology and Biophysics
- Skin Barrier Function Analysis
Background:
- The stratum corneum's structure and dynamics are crucial for skin barrier function.
- Assessing these properties often requires specialized techniques.
Purpose of the Study:
- To introduce and detail the squamometry technique for evaluating the stratum corneum.
- To present four distinct variants of the squamometry index for specific applications.
Main Methods:
- Utilizing calibrated stripping with adhesive-coated discs (SACD) to obtain stratum corneum samples.
- Employing a toluidine blue-basic fuchsin ethanol-based staining solution.
- Measuring the colorimetric variable Chroma C* to derive the squamometry index.
Main Results:
- Developed four squamometry index variants: X (xerosis), L (UV-induced cohesiveness), R (renewal), and S (surfactant effects).
- Squamometry provides a rapid, reliable, sensitive, and inexpensive method for skin assessment.
Conclusions:
- Squamometry is a versatile and efficient tool for analyzing various aspects of stratum corneum integrity and dynamics.
- The technique offers practical applications in research and clinical settings for skin condition evaluation.
