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Published on: December 9, 2022
[RANTES expression in venous ulceration of lower limbs]
Liu-hua Chen1, Cai-sheng Ye, Heng-hui Yin
1Department of Vascular Surgery, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou 510080, China. chlh22@163.com
Objective:
To investigate the expression of RANTES in venous ulceration.
Methods:
From patients with lower limb venous ulceration, patients with non-ulcerous venous insufficiency, and healthy individuals, peripheral blood was collected from the lower limb veins for measurement of RANTES mRNA using RT-PCR.
Results:
In the ulceration group, the expression of RANTES mRNA was significantly increased as compared with the other two groups (P<0.01). RANTES mRNA expression was also significant higher in the non-ulcerous group than the control group (P<0.01).
Conclusion:
High expression of RANTES mRNA may be one of the important mechanisms of venous ulceration.
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