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Fibrinolytic poly(dimethyl siloxane) surfaces.

Hong Chen1, Liang Wang, Yanxia Zhang

  • 1State Key Laboratory of Advanced Technology for Materials Synthesis and Processing, and School of Materials Science and Engineering, Wuhan University of Technology, Wuhan 122 Luoshi Rd. 430070, China. hongchen@whut.edu.cn

Macromolecular Bioscience
|May 28, 2008
PubMed
Summary
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Modified polydimethylsiloxane (PDMS) surfaces resist protein adsorption and lyse blood clots. These advancements in biomaterial coatings show promise for improved medical devices by reducing unwanted protein buildup and enhancing clot dissolution capabilities.

Area of Science:

  • Biomaterials Science
  • Surface Chemistry
  • Biomedical Engineering

Background:

  • Polydimethylsiloxane (PDMS) is widely used in biomedical devices but suffers from non-specific protein adsorption and lack of clot-lysing properties.
  • Protein adsorption can lead to device failure, immune responses, and thrombosis.
  • Developing surfaces with enhanced biocompatibility and active clot-dissolving capabilities is crucial for advanced medical applications.

Purpose of the Study:

  • To modify PDMS surfaces to resist non-specific protein adsorption.
  • To impart clot-lysing properties to PDMS surfaces.
  • To characterize the modified surfaces and evaluate their performance in protein adsorption and clot lysis.

Main Methods:

  • Surface modification of PDMS using polyethylene glycol (PEG) and lysine immobilization.

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  • Characterization techniques: water contact angle, Attenuated Total Reflectance Fourier-Transform Infrared (ATR FT-IR) spectroscopy, X-ray Photoelectron Spectroscopy (XPS).
  • Assessment of protein adsorption using radiolabeled fibrinogen uptake and plasminogen adsorption from human plasma.
  • In vitro evaluation of clot lysis on modified surfaces exposed to plasma and tissue plasminogen activator.

    • Main Results:

    • Modified PDMS surfaces demonstrated resistance to non-specific protein adsorption, confirmed by reduced fibrinogen uptake.
    • Lysine-immobilized surfaces exhibited clot-lysing properties.
    • Surface characterization confirmed successful modification and presence of functional groups.
    • Effective fibrin clot dissolution was observed on modified surfaces upon activation with plasma and tissue plasminogen activator.

    Conclusions:

    • PDMS surfaces can be successfully modified to achieve both protein adsorption resistance and clot-lysing capabilities.
    • The developed surface modifications offer potential for creating advanced biomaterials with improved hemocompatibility.
    • These findings suggest applications in medical devices where control over protein interactions and thrombus management is essential.