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Systems biology approaches for the study of multiple sclerosis

Francisco J Quintana1, Mauricio F Farez, Howard L Weiner

  • 1Center for Neurologic Diseases, Harvard Medical School, Boston, MA 02115, USA. fquintana@rics.bwh.harvard.edu

Journal of Cellular and Molecular Medicine
|May 29, 2008
PubMed

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Multiple sclerosis is a chronic autoimmune disease of the central nervous system (CNS) that affects the brain, spinal cord, and optic nerves. It is an inflammatory demyelinating disorder and a leading cause of neurological disability in young adults.EpidemiologyMS commonly begins between 20 and 40 years of age and is twice as common in women. Its exact cause remains unclear, but genetic susceptibility contributes, with higher risk in first-degree relatives and identical twins. A greater...