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Hormone effects on specific and global brain functions.

A W Lee1, D W Pfaff

  • 1Laboratory of Neurobiology and Behavior, The Rockefeller University, New York, NY 10021, USA.

The Journal of Physiological Sciences : JPS
|May 29, 2008
PubMed
Summary
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Estrogen

Area of Science:

  • Neurobiology
  • Endocrinology
  • Behavioral Neuroscience

Background:

  • Female reproductive behaviors are guided by biochemical changes in specific brain regions.
  • Estrogens influence hypothalamic neurons, facilitating lordosis behavior in female mammals.
  • Sexual behaviors are contingent upon sexual arousal, which relies on generalized central nervous system (CNS) arousal.

Purpose of the Study:

  • To elucidate the neurobiological mechanisms by which generalized arousal transmitters influence female sexual behavior.
  • To demonstrate how norepinephrine affects the electrical excitability of ventromedial hypothalamic neurons to promote female sexual behavior.

Main Methods:

  • Review and summarization of existing research on estrogen's effects on hypothalamic neurons.
  • Analysis of the role of norepinephrine as a generalized arousal transmitter.

Related Experiment Videos

  • Investigation of norepinephrine's influence on the electrical properties of ventromedial hypothalamus cells.

    • Main Results:

    • Estrogens directly impact hypothalamic neurons to facilitate lordosis behavior.
    • Norepinephrine, a key arousal transmitter, modulates the electrical excitability of ventromedial hypothalamic neurons.
    • This modulation by norepinephrine is a critical pathway fostering female sexual behavior.

    Conclusions:

    • Biochemical changes in specific neurons, particularly estrogen's effects in the hypothalamus, are fundamental to mammalian reproductive behaviors.
    • Generalized CNS arousal, mediated by transmitters like norepinephrine, is essential for sexual arousal and subsequent sexual behavior.
    • Norepinephrine's influence on hypothalamic neuronal excitability provides a key neurobiological link between arousal and female sexual behavior.